KẾT QUẢ PHẪU THUẬT UNG THƯ LƯỠI GIAI ĐOẠN III, IV (M0) SAU HÓA CHẤT TÂN BỔ TRỢ TẠI BỆNH VIỆN K

Abstract

Objectives: This study was conducted to report clinicals, subclinicals and evaluate the results of surgery in stage III,IV(M0) tonge cancer post neoadjuvant chemotherapy at Vietnam National Cancer Hospital. Patients and methods: A retrospective, descriptive study on 63 patients with neoadjuvant chemotherapy tongue cancer patients were operated in K hospital from 01/2014 to 12/2020. Results: Mean age 51.3; male/female: 3.6/1; the most common position of tumor is the edge of tongue 87.3%; 53.9% tumor over 4cm, 79.4% lymph node less than 3cm, chemotherapy regimens TCF 9.5% TC 57.1% CF 33.4%; Complete response 11.1% , partial reponse 62.4%, stable disease 26.3%. The main surgical method is hemiglossectomy and neck lymph node dissection 61.9%, the surgical complications is rare, the most common complications are flap necrosis and salivary leakage 4.8%. 5 years overall survival was 24.1%, of stage III group was 48.1%, stage IV group was 8.1%. Conclusion: Tongue cancer is common in middle-aged men, the disease is often detected at an advanced stage. Surgery is the main treatment. Neo-adjuvant chemotherapy helps shrink tumors and lymph nodes, facilitating surgery. The choice of chemotherapy regimen, surgical methods of tumor removal and reconstruction depends on the patient's performance status and the experience of the physician. The survival time of the stage III group was higher than that of the stage IV(M0) group.