THỰC TRẠNG ĐỀ KHÁNG KHÁNG SINH CỦA E.COLI PHÂN LẬP ĐƯỢC TẠI BỆNH VIỆN NHI HẢI DƯƠNG NĂM 2023

Abstract

Background: E.coli is known to be a common cause of many common clinical infections such as gastrointestinal infections, urinary tract infections, respiratory infections, sepsis... but there are Severe complications in pediatric patients and high rate of antibiotic resistance. Providing information about the antibiotic resistance situation of E.coli at Hai Duong Children's Hospital is very necessary for clinicians. Research objective: Determine the antibiotic resistance rate, ESBL production rate, carbapenem production rate of E.coli isolated at Hai Duong Children's Hospital from January to June 2023. Research subjects and methods: Cross-sectional descriptive study conducted on 167 E.coli strains, collected from cultures of patient samples from pediatric patients at Hai Duong Children's Hospital in the first 6 months of 2022. Progress Perform bacterial identification techniques, antibiogram, ESBL test using double disc paper compartment and test Carbapenemase production ability using Hodge test technique. Results: E.coli was the most resistant to ampicillin at 90.18%, followed by trimethoprim-sulfamethoxazole at 81.97%, however E.coli was also highly sensitive to carbapenemase antibiotics (97%) and amikacin (89.97%). The rate of multidrug resistance is 77.25%. The ESBL and carbapenemase production rates of E.coli are 12.57% and 3.59%, respectively. Research also shows that strains that produce ESBL and carbapenemase are much more resistant to antibiotics than strains that do not produce these enzymes. Conclusion: E.coli strains in our study have relatively high rates of antibiotic resistance and multidrug resistance. The ESBL and carbapenemase production rate of E.coli is low and affects the antibiotic resistance of the bacterial strain.