KHÁNG THỂ KHÁNG BÀO TƯƠNG BẠCH CẦU ĐA NHÂN TRUNG TÍNH TRONG BỆNH LUPUS BAN ĐỎ HỆ THỐNG

Abstract

Objectives: My research aims to examine the role of antineutrophil cytoplasmic antibodies in systemic lupus erythematosus. Methods and Methodology: This is cross-sectional descriptive study on 115 patients diagnosed with systemic lupus erythematosus according to SLICC 2012 Standard treated at the center of Allergology and Clinical Immunology in Bach Mai hospital from July 2020 to September 2021. Results: the percentage of antibodies ANCA, MPO – ANCA, PR3-ANCA being positive are 33%,3.5%, 32.2%, respectively. The positive antibody PR3-ANCA is relevant to the patients whose illness time is less than 2 years (p=0.05). The common clinical characteristics in the SLE patients with positive ANCA, c-ANCA are arthritis (57.9% and 56.8%), acute skin rash - butterflu rash (26.3% and 24.3%), interstitial lung disease (26.3% and 24.3%), multi membrane effusion (34.2% and 35.1 %), ulcers in skin ((18.4% và 18.9%), Raynaud (16.2% và 16.7%), C3 deficiency (97.4% and 97.3%), C4 deficiency (84.2% and 83.8%) and 100% of SLE patients who have positive ANCA, c – ANCA antibodies has positive dsDNA. The positive ANCA antibody in SLE patients relevant to characteristics such as ulcers in skin chi (OR= 4.121, p = 0.038), Raynaud (OR= 7.258, p = 0.014), C4 deficiency (OR= 4, p = 0.004), surplus dsDNA (OR= 1.561, p = 0.029), severe disease activity level (OR=2.829, p=0.017). Conclusions: Patients diagnosed with systemic lupus erythematosus have ANCA antibody which is relevant to severe disease activity level and skin damage, Raynaud. There is no link or corelation between ANCA antibody with kidney damage in SLE.