ĐẶC ĐIỂM TRẺ TAY CHÂN MIỆNG THỞ MÁY

Abstract

Objective: To describe the epidemiological, clinical, laboratory characteristics, and treatment outcomes of children with hand, foot, and mouth disease (HFMD) requiring mechanical ventilation in the Infectious Diseases Intensive Care Unit, Children’s Hospital 1. Methods: A descriptive case series study was conducted on all HFMD patients who required mechanical ventilation in the Infectious Diseases Intensive Care Unit, Children’s Hospital 1, from January 2023 to December 2023. Results: A total of 118 children with HFMD required mechanical ventilation. The median age was 22 months, with 86.4% under 36 months. Most admissions occurred during July–August and November. Neurological complications were observed in all patients. The most common associated symptoms were apnea (77.1%), startle (75.4%), tachypnea (43.2%), and hypertension (39.8%). The most frequent abnormal laboratory finding was lactate > 2 mmol/L (54.2%), followed by platelet count > 400 k/μL (39.0%) and neutrophil/lymphocyte ratio > 2 (27.1%). EV-A71 was detected in 11 cases (9.3%). The main indication for intubation was apnea (74.6%). All patients received intravenous immunoglobulin (IVIG), with 66.9% receiving two doses. There were 2 deaths (1.7%) and 14.4% had neurological sequelae. Conclusion: HFMD remains a common infectious disease, particularly among children under 36 months of age. Children with HFMD requiring mechanical ventilation frequently present with apnea and shallow, rapid breathing. Further studies are warranted to clarify the role of IVIG therapy in this group of patients.