ĐÁNH GIÁ SỰ BỘC LỘ CỦA THỤ THỂ PROGESTERONE TRONG UNG THƯ BIỂU MÔ TUYẾN VÚ

Abstract

Background: Breast cancer remains one of the most prevalent malignancies among women in Vietnam. Approximately 70% of breast cancers are hormone receptor–positive (ER and/or PR). Hormone receptor status plays a critical role in determining prognosis and guiding endocrine therapy, which substantially reduces recurrence and improves survival. Objectives: To assess the expression of the progesterone receptor (PR) in invasive breast carcinoma and analyze its association with selected histopathological features. In addition, to compare PR expression between core needle biopsy samples and surgical specimens. Methods: This cross-sectional study included 103 paraffin-embedded breast tissue samples obtained from female patients diagnosed histopathologically with invasive breast carcinoma who underwent surgery at Hanoi Medical University Hospital from January 2024 to June 2025. PR expression was evaluated according to the Allred scoring system. Data were analyzed using SPSS version 26.0. Results: PR positivity was detected in 66.0% of breast carcinoma cases, with the low-positive group (1–10%) accounting for 7.8%. Positive PR expression was significantly more common in patients aged ≤45 years and in tumors of histologic grade II (p < 0.05). There was good concordance between PR expression in core biopsy and surgical specimens (κ = 0.695). Conclusion: PR was positive in 66.0% of breast carcinoma cases, including 7.8% with low expression (1–10%). PR assessment showed good agreement between core needle biopsy and surgical specimens, supporting the reliability of biopsy evaluation in routine diagnostic practice.