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ANALYSIS OF ANTIBIOTIC USE IN HOSPITALIZED PATIENTS WITH CHRONIC KIDNEY DISEASE AT A MEDICAL FACILITY IN SOUTHERN VIETNAM IN 2025
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Abstract
Introduction: Chronic kidney disease (CKD) is a leading cause of death and has shown a steadily increasing mortality rate over the past two decades, affecting more than 10% of the global population. This study aims to analyze antibiotic utilization and evaluate the rationality of antibiotic therapy in the treatment of chronic kidney disease at Giồng Riềng District Medical Center, Kiên Giang Province, in 2025. Objectives: 1) To describe the pattern of antibiotic use among hospitalized patients with chronic kidney disease. 2) To evaluate the rationality of antibiotic utilization and identify factors associated with antibiotic use in hospitalized patients with chronic kidney disease. Methods: A descriptive cross-sectional study was conducted using retrospective data from 115 medical records of patients aged 18 years and older who were diagnosed with chronic kidney disease and received antibiotic treatment at a medical facility in southern Vietnam from January 1, 2025, to June 30, 2025. Results: Patients with chronic kidney disease had a mean age of 66.1 ± 14.2 years, with diabetes mellitus (27.83%) and heart failure (21.74%) being the most common comorbidities. Ceftriaxone was the most frequently used antibiotic (69.57%), and the treatment duration was predominantly between 8–14 days (55.65%). Monotherapy regimens accounted for 87.83%, while 95.65% of patients showed clinical improvement, highlighting the importance of antibiotic dose adjustment in reducing the risk of hemodialysis. Conclusions: The rate of antibiotic dose adjustment according to clinical guidelines in the treatment of chronic kidney disease remains low. Recommendations include: 1) Enhancing training programs for physicians and pharmacists on renal function assessment and dose adjustment. 2) Developing standardized protocols for antibiotic prescribing and dose modification. 3) Strengthening regular monitoring of renal function. 4) Promoting the use of monotherapy regimens when appropriate. 5) Increasing patient awareness of proper dosing and treatment adherence
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Keywords
Antibiotic use; appropriateness (rational use); chronic kidney disease (CKD).
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