NGHIÊN CỨU ẢNH HƯỞNG TÌNH TRẠNG MẤT ỔN ĐỊNH VI VỆ TINH (MSI) VÀ HUMAN PAPILLOMAVIRUS (HPV) TRÊN UNG THƯ ĐẠI TRỰC TRÀNG

Abstract

Objective: To determine the prevalence of Human Papillomavirus (HPV) infection in patients with primary colorectal cancer (CRC) and to evaluate its association with microsatellite instability (MSI) status. Subjects and Methods: This cross-sectional study included 98 formalin-fixed, paraffin-embedded (FFPE) samples derived from patients diagnosed with primary colorectal cancer (CRC) at Hanoi Medical University Hospital during 2021-2023. HPV DNA was amplified by PCR method, and MSI status was assessed by immunohistochemistry. Data were processed and statistically analyzed using GraphPad Prism 10 software. Results: Among 98 cases, HPV infection was detected in 35 cases (35.7%). MSI was identified in 18 cases (18.4%), mainly observed in stage I and II tumors without lymph node or distant metastasis (p = 0.01). No significant association was found between HPV infection and age, sex, histopathological classification, or MSI status (p > 0.05). Conclusion: MSI status in CRC does not appear to be significantly influenced by HPV infection. However, the detection of HPV in 35.7% of primary CRC cases in this study suggests that HPV may represent a potential risk factor in colorectal carcinogenesis.