ĐỀ KHÁNG INSULIN VÀ MỘT SỐ YẾU TỐ LIÊN QUAN TRÊN BỆNH NHÂN TIỀN ĐÁI THÁO ĐƯỜNG TẠI BỆNH VIỆN NỘI TIẾT NGHỆ AN NĂM 2025

Abstract

Objectives: To determine the prevalence of insulin resistance and analyze associated factors among patients with prediabetes at Nghe An Endocrinology Hospital in 2025. Methods: A cross-sectional study was conducted on 116 patients aged 18 years and older who were newly diagnosed with prediabetes. Insulin resistance was defined using the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) with a cutoff value of ≥1.878. Demographic, clinical, and biochemical data were collected and analyzed using multivariate logistic regression. Results: The prevalence of insulin resistance in the study population was 26.7%. Multivariate analysis revealed that HbA1c ≥5.7% was an independent risk factor associated with IR (OR = 5.51; 95%CI: 1.42–21.43; p = 0.04). Other statistically significant associated factors included low physical activity (OR = 3.91; 95%CI: 1.38–11.03), increased waist circumference (OR = 3.85; 95%CI: 1.58–9.37), dyslipidemia (OR = 3.80; 95%CI: 1.60–9.23), and a family history of diabetes (OR = 2.64; 95%CI: 1.03–6.81). Conclusions: The main risk factors for insulin resistance among prediabetic patients were elevated HbA1c, low physical activity, abdominal obesity, and dyslipidemia. The findings highlight the importance of IR screening and lifestyle management to prevent progression to type 2 diabetes.