RELATIONSHIP BETWEEN ARRHYTHMIC COMPLICATIONS, PUMP FAILURE AND CLINICAL PHENOTYPES IN PATIENTS WITH ACUTE MYOCARDITIS
Main Article Content
Abstract
Objective: To investigate the clinical subtypes, arrhythmic complications, pump failure, and the interrelationship among these factors in patients with acute myocarditis admitted to Cho Ray Hospital. Methods: This retrospective descriptive study included 218 patients diagnosed with acute myocarditis based on clinical presentation, elevated cardiac biomarkers, and cardiac MRI findings. Data on clinical type, arrhythmia pattern, left ventricular ejection fraction (LVEF), and heart failure status were analyzed using Stata 17.0, with statistical significance set at p < 0.05. Results: Among 218 patients, 62 (28.4%) had fulminant myocarditis and 156 (71.6%) had acute non-fulminant myocarditis. Arrhythmias were observed in 71.1% of cases, with ventricular arrhythmias being the most frequent (39.0%). Pump failure occurred in 54.6% of patients, of whom 28.4% had LVEF < 35%. Fulminant cases had significantly higher rates of arrhythmias and pump failure than non-fulminant cases (p < 0.001). Correlation analysis demonstrated a strong association between ventricular arrhythmia and severe LVEF reduction, suggesting extensive myocardial injury. Conclusion: Arrhythmia, pump failure, and clinical subtype are closely interrelated in acute myocarditis. The coexistence of ventricular arrhythmia and reduced LVEF indicates diffuse myocardial damage and identifies a subgroup of patients at high risk who require intensive monitoring and early intervention.
Article Details
Keywords
acute myocarditis, arrhythmia, pump failure, fulminant type, left ventricular ejection fraction.
References
2. Lampejo T, Durkin SM, Bhatt N, Guttmann O. Acute myocarditis: aetiology, diagnosis and management. Clin Med (Lond). Sep 2021;21(5): e505–e510. doi:10.7861/clinmed. 2021-0121
3. Cooper LT, Jr. Myocarditis. N Engl J Med. Apr 9 2009;360(15): 1526–38. doi:10.1056/ NEJMra0800028
4. Kindermann I, Barth C, Mahfoud F, et al. Update on myocarditis. J Am Coll Cardiol. Feb 28 2012; 59(9): 779–92. doi:10.1016/j.jacc.2011. 09.074
5. Pavlicek V, Kindermann I, Wintrich J, et al. Ventricular arrhythmias and myocardial inflammation: Long-term follow-up of patients with suspected myocarditis. Int J Cardiol. Jan 1 2019; 274: 132–137. doi:10.1016/j.ijcard.2018. 07.142
6. Rosier L, Zouaghi A, Barré V, et al. High Risk of Sustained Ventricular Arrhythmia Recurrence After Acute Myocarditis. J Clin Med. Mar 20 2020;9(3)doi:10.3390/jcm9030848
7. Ammirati E, Frigerio M, Adler ED, et al. Management of Acute Myocarditis and Chronic Inflammatory Cardiomyopathy: An Expert Consensus Document. Circ Heart Fail. Nov 2020;13(11): e007405. doi:10.1161/circheart failure.120.007405
8. McCarthy RE, 3rd, Boehmer JP, Hruban RH, et al. Long-term outcome of fulminant myocarditis as compared with acute (nonfulminant) myocarditis. N Engl J Med. Mar 9 2000; 342(10): 690–5. doi:10.1056/ nejm200003093421003
9. Ammirati E, Veronese G, Brambatti M, et al. Fulminant Versus Acute Nonfulminant Myocarditis in Patients With LPSTMt Ventricular Systolic Dysfunction. J Am Coll Cardiol. Jul 23 2019; 74(3): 299–311. doi:10.1016/j.jacc.2019. 04.063
10. Heymans S, Van Linthout S, Kraus SM, Cooper LT, Ntusi NAB. Clinical Characteristics and Mechanisms of Acute Myocarditis. Circ Res. Jul 5 2024; 135(2): 397–411. doi:10.1161/ circresaha.124.324674