YẾU TỐ LIÊN QUAN TÌNH TRẠNG GIẢM TIỂU CẦU Ở TRẺ EM MẮC SỐT XUẤT HUYẾT DENGUE TẠI BỆNH VIỆN QUỐC TẾ GREEN

Abstract

Objectives: Describe clinical and paraclinical characteristics and analyze some factors related to thrombocytopenia in children with dengue fever at Green International Hospital in 2024. Meterials and methods: Retrospective descriptive study on 158 children < 16 years old treated at the Department of Pediatrics, Green International Hospital from January 1, 2024 to December 31, 2024. Results: Male (56.3%), female (43.7%). The average age was 7.94 ± 0.6, the most common is 7 to 12 years old (44.3%). Fever 100%, subcutaneous bleeding 99.4%, mainly in the form of spots (65.8%). Warning signs (96.2%), commonly increasing abdominal pain: (36.7%). Leukopenia (58.2%), thrombocytopenia (55.7%), increased hematocrit (37.6%), increased AST/ALT (peak day 3–5). Factors associated with thrombocytopenia: female gender (OR = 2.0; p = 0.03, CI: 1-4), leukopenia (OR = 2,67; p = 0.003, CI: 1.3-5.4), increased ALT (OR = 2,2, p = 0.026, CI: 1-4,8). A fairly strong negative linear correlation was observed between platelet count and hematocrit during the first two days of treatment (r = -0.6, p = 0.02). Conclusions: Clinical characteristics: the rate of male and female patients is the same, the disease is common in school-age children. All cases had fever, the main bleeding pattern was petechiae. Factors associated with thrombocytopenia were female gender, leukopenia, increased ALT, and hematocrit.