OUTCOMES OF INTRACAPSULE INJECTION OF PLATELET RICH PLASMA IN KNEE OSTEOATHRITIS PATIENTS AT CANTHO UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL

Lâm Minh Tân Nguyễn 1,2,, Thành Tấn Nguyễn 1,2, Lê Hoan Nguyễn 1,2, Phước Giàu Đặng 1,2, Hữu Đạt Nguyễn 1,2, Việt Tân Phạm 2, Kim Hiệu Huỳnh 1
1 Can Tho University of Medicine and Pharmacy
2 Can Tho University of Medicine and Pharmacy Hospital

Main Article Content

Abstract

Background: Knee osteoarthritis is a common condition that significantly impacts patients' quality of life. Intra-articular platelet-rich plasma (PRP) injection has emerged as a widely used and effective conservative treatment approach. Methods: This retrospective cross-sectional study was conducted on patients with knee osteoarthritis of grades 1, 2, and 3 who received intra-articular PRP injections at Can Tho University of Medicine and Pharmacy Hospital from January 2022 to December 2022. Results: A total of 29 patients with knee osteoarthritis were included, with a mean age of 58.4 ± 11.4 years; 26 of the 29 (89.7%) were female. The Visual Analog Scale (VAS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores showed statistically significant improvement at 6 months post-injection (VAS mean 1.3 ± 1.4, WOMAC mean 16.6 ± 11.6; p < 0.001). Body mass index (BMI) was found to significantly affect treatment outcomes (R² (ΔVAS) = 0.347; R² (ΔWOMAC) = 0.341; p < 0.05). Conclusion: Intra-articular PRP injection for knee osteoarthritis has shown significant improvements in VAS and WOMAC scores after 6 months of treatment.

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References

1. Cross M, Smith E, Hoy D, et al. The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study. Ann Rheum Dis. 2014;73(7):1323–1330.
2. Bannuru RR, Osani MC, Vaysbrot EE, et al. OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthritis Cartilage. 2019;27(11):1578–1589.
3. Shen L, Yuan T, Chen S, et al. The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials. J Orthop Surg Res. 2017;12:16.
4. Dai WL, Zhou AG, Zhang H, Zhang J. Efficacy of platelet-rich plasma in the treatment of knee osteoarthritis: A meta-analysis of randomized controlled trials. Arthroscopy. 2017;33(3):659–670.
5. Filardo G et al. Platelet-rich plasma intra-articular knee injections show no superiority versus viscosupplementation: a randomized controlled trial. Am J Sports Med. 2015;43(7):1575–1582.
6. Smith PA. Intra-articular autologous conditioned plasma injections provide safe and efficacious treatment for knee osteoarthritis. Am J Sports Med. 2016;44(4):884–891.
7. Görmeli G et al. Multiple PRP injections are more effective than single injections and hyaluronic acid in knees with early osteoarthritis: a randomized, double-blind, placebo-controlled trial. Knee Surg Sports Traumatol Arthrosc. 2017 Mar; 25(3):958-965.