ĐÁNH GIÁ TÌNH HÌNH SỬ DỤNG THUỐC ỨC CHẾ BƠM PROTON TRÊN BỆNH NHÂN VIÊM LOÉT DẠ DÀY – TÁ TRÀNG TẠI KHOA NỘI TỔNG QUÁT BỆNH VIỆN ĐẠI HỌC NAM CẦN THƠ NĂM 2024

Abstract

Objectives: To examine PPI utilization patterns and assess appropriateness by indication, dose, route, and duration, while evaluating factors associated with inappropriate dosing. Subjects and Methods: A retrospective descriptive study of 83 inpatient records at the Department of General Medicine, Nam Can Tho University Hospital, in 2024. Epidemiologic characteristics, endoscopic findings, comorbidities, concomitant medications, and PPI details were collected. Results: Females accounted for 44.6%, with age mainly distributed at < 20 years 37.3% and 41–60 years 26.5%. Endoscopic lesions were mild in 56.6% and moderate in 36.1%. Esomeprazole comprised 60.0% of episodes, followed by omeprazole 26.2% and pantoprazole 11.5%. The 40-mg dose accounted for 76.9%; mean duration was 5 days with a median of 4 days. Appropriateness reached 100% for indication and 100% for route and duration among those with an indication. Dose appropriateness was 88.0% (73/83); inappropriate dosing did not differ by sex (p = 0.746; OR for “appropriate dose” = 1.28; 95% CI 0.34–4.81). Patients not using NSAIDs had 18.5% inappropriate dosing (10/54) versus 0% in NSAID users (0/29), Fisher p = 0.013. The proportion of inappropriate dosing was significantly higher in the H. pylori–positive group than in the negative group (Fisher p < 0.001). The odds of inappropriate dosing were ~648 times higher in the infected group (OR = 648; 95% CI 37.22–11282.46). Conclusions: Overall PPI use at the facility aligned with recommendations; optimization should focus on reducing active-ingredient duplication and tailoring doses to specific indications, particularly when H. pylori infection is absent.