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EFFECT EVALUATION OF RECOMBINANT LUMBROKINASE ON ACUTE BRAIN INFARCTION MICE MODEL
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Abstract
Objectives: Acute brain infarction was induced to evaluate the effect of recombinant lumbrokinase on mice’s motor function. Methods: Model of acute cerebral infarction in the middle cerebral artery of mice according to the method of Cyrille Orset et al, methods to evaluate the effect of drugs on the degree of motor function damage in mice during the acute phase. Results and conclusion: The cerebral infarction mice model used in this study allowed the creation of a blood clot that are similar to clinical reality; the recombinant lumbrokinase 200mg/kg recover motor function of cerebral infarction mice on an experimental model during the acute phase.
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Keywords
lumbrokinase, model of cerebral infarction, mice
References
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