NGHIÊN CỨU ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG CỦA BỆNH NHÂN UNG THƯ HẠ HỌNG CÓ KHỐI UNG THƯ NGUYÊN PHÁT THỨ HAI

Abstract

Objectives: To study clinical and paraclinical characteristics of patients with hypopharyngeal cancer with second primary tumor. Methods & Materials: Cross-sectional study of 41 patients with hypopharyngeal cancer with second primary tumor cat  National Hospital of Otolaryngology. Results: The rate of occurrence of second primary tumor was 4.7%. 41 patients with hypopharyngeal cancer with second primary tumor were all men, mean age 57.34 ± 6.95 years, most had a history of tobacco and alcohol use for many years. The most common clinical symptom is swallowing disorders (97.6%): dysphagia 80.5%, odynophagia 53.7%, swallowing choking 14.6%, hoarseness 34.1%, patient weight loss clearly weighed 24.4%. The most common tumor was in the T2 stage, accounting for 46.3% and the T3 stage for 36.6%, and 12.2% in the T1 stage. Clinically, there are 90.2% of patients with no suspected metastasis nodes, 7.3% of patients at stage N1 and only 1 patient at stage N2. 97.6% of patients had a second primary tumor in the esophagus, only 1 patient had a second primary cancer in the oropharyngeal. The middle third of the esophagus is the most common site for cancer lesions in 56.8%. 100% of patients with squamous carcinoma, mostly histological grade III. Conclusion: Patients with hypopharyngeal cancer in particular and head and neck carcinoma have a high risk of having a second primary cancer, which increases the poor prognosis, affects the treatment plan, and the survival of the patient. The second primary tumor is usually located in the upper aerodigestive tract and lung. The varied clinical symptoms are often masked by the symptoms of the primary tumor. In the management of cancer patients, a second primary tumor should be sought in all patients with hypopharyngeal cancer prior to primary tumor treatment.