Article Sidebar
Views PDF: 24
PREPARATION OF PIPERIN MICROPARTICLES WITH SODIUM ALGINATE FOR APPLICATION IN DERMATOLOGICAL TREATMENT
Main Article Content
Abstract
Objectives: The aim of this study was to prepare the piperin microparticles and prepare gel containing the piperin microparticles. Methods: The piperin microparticles was prepared by using the emulsion-solvent evaporation methods. The obtained nanoparticles were characterized, including the particles size, polydispersity index, zeta potential and encapsulation efficiency. The gel containing piperin microparticles were evaluated, include pH value, stability of pH value, ability of gel forming. Results: The formulation of microparticles was built, including piperin 10 mg, with the particle size was 206,73 ± 2,96 nm, PDI was 0,297 ± 0,009 and the encapsulation efficiency was 83,45 ± 0,25%. The formulation of gel was built, including Carbopol 940 0,8% and HPMC E15 2,0%. The gel was good at adhesion and pH value’s stability.
Article Details
Keywords
piperin, natri alginat, piperin microparticles.
References
2. Lu H, Gong H, Du J, et al. Piperine ameliorates psoriatic skin inflammation by inhibiting the phosphorylation of STAT3. Int Immunopharmacol 2023; 119: 110221.
3. Chapoval S, Dasgupta P, Dorsey NJ, et al. Regulation of the T helper cell type 2 (Th2)/T regulatory cell (Treg) balance by IL-4 and STAT6. J Leukoc Biol 2010; 87: 1011–1018.
4. Politi FAS, Carvalho SG, Rodero CF, et al. Piperine-loaded nanoparticles incorporated into hyaluronic acid/sodium alginate-based membranes for the treatment of inflammatory skin diseases. Int J Biol Macromol 2023; 227: 736–748.
5. Suruchi Singh, Harsh Rastogi, Varsha Singh, et al. Alginate based Nanoparticles and Its Application in Drug Delivery Systems. J Pharm Negat Results 2022; 13: 1463–1469.
6. Sheshala R, Ming NJ, Kok YY, et al. Formulation and characterization of pH induced in situ gels containing sulfacetamide sodium for ocular drug delivery: A combination of Carbopol®/HPMC polymer. Indian Journal of Pharmaceutical Education and Research 2019; 53: 654–662.
7. Espinosa-Andrews H, Páez-Hernández G. Optimization of ultrasonication curcumin-hydroxylated lecithin nanoemulsions using response surface methodology. J Food Sci Technol 2020; 57: 549–556.
8. Kumar H, Kumar V. Ultrasonication assisted formation and stability of water-in-oil nanoemulsions: Optimization and ternary diagram analysis. Ultrason Sonochem 2018; 49: 79–88.
9. Sharma T, Kumar GS, Chon BH, et al. Thermal stability of oil-in-water Pickering emulsion in the presence of nanoparticle, surfactant, and polymer. J Ind Eng Chem 2015; 22: 324–334.