ĐÁNH GIÁ CÁC CHỈ SỐ NEUTROPHIL/LYMPHOCYTE RATIO, PLATELET/LYMPHOCYTE RATIO VÀ PLATELET/NEUTROPHIL RATIO Ở BỆNH NHÂN CÓ TÌNH TRẠNG NHIỄM KHUẨN TẠI BỆNH VIỆN THANH NHÀN

Abstract

Objective: To evaluate the Neutrophil/Lympho (NLR), Platelet/Lympho (PLR) and Platelet/Neutrophil (PNR) indices in patients with infections at Thanh Nhan Hospital and analyze the relationship between the NLR, PLR, and PNR indices with some inflammatory markers. Subjects and methods: Cross-sectional descriptive study on 199 infected patients treated at Thanh Nhan Hospital from January 2025 to October 2025 and 372 healthy people to establish reference ranges. Results: The mean values ​​of the NLR, PLR, and PNR indices in the healthy control group were 1.71 + 0.92, respectively; 109.51 + 34.13 and 70.45 + 22.94 with 95% value ranges of 1.61 - 1.80; 106.11 - 113.06 and 68.29 - 75.18, respectively. The mean values ​​of NLR, PLR and PNR indices in the infected group were 10.52 + 14.47; 237.58 + 386.94 and 34.63 + 29.91, respectively, with 95% value ranges of 8.49 - 12.54; 183.49 - 291.67 and 30.45 - 38.81, respectively. In terms of diagnostic value in bacterial infection, the NLR index with a cut-off point of 2.67 had a sensitivity of 81.4% and a specificity of 92.5%, AUC = 0.915, the PLR ​​index with a cut-off point of 156.17 had a sensitivity of 51.3% and a specificity of 91.7%, AUC = 0.715. The NLR index had a moderate positive correlation with WBC, NEUT#, PCT and IL6 with correlation coefficients of 0.327; 0.468; 0.357 and 0.355, respectively, (p < 0.05). The PLR ​​index had a weak positive correlation with PCT with a correlation coefficient of 0.197 (p < 0.05). PNR index had a strong negative correlation with WBC and NEUT# with correlation coefficients of - 0.519 and - 0.567 respectively (p < 0.05); a weak negative correlation with CRP with correlation coefficients of - 0.204 (p < 0.05).