Article Sidebar

pdf
Date Published: 11/03/2026
Abstract Views: 37
Views pdf: 34
DOI: https://doi.org/10.51298/vmj.v559i3.17654
Issue
Vol. 559 No. 3 (2026)
Section
Các bài báo
How to Cite
Phan, T. H., Lâm, V. N., Phạm, N. H. P., Lê, T. P. D., Phạm, N. H., Hứa, T. M. H., & Văng, T. T. L. (2026). THE PREVALENCE OF POSITIVE THYROID AUTOANTIBODIES AND THYROID DYSFUNCTION IN INFERTILE WOMEN. Vietnam Medical Journal, 559(3). https://doi.org/10.51298/vmj.v559i3.17654

THE PREVALENCE OF POSITIVE THYROID AUTOANTIBODIES AND THYROID DYSFUNCTION IN INFERTILE WOMEN

Thị Hằng Phan, Vĩnh Niên Lâm, Nguyễn Hữu Phúc Phạm, Thị Phương Dung Lê, Nguyên Huân Phạm, Thị Mỹ Huyền Hứa, Thị Trúc Linh Văng

Main Article Content

Abstract

Objective: To determine the prevalence of positive thyroid autoantibodies and thyroid dysfunction in infertile women. Methods: This study subjects included women who met the World Health Organization (WHO) diagnostic criteria for infertility and underwent testing for TSH, FT4, TPOAb, and TGAb. The related factors surveyed included: age, BMI, history of miscarriage or stillbirth, type of infertility, prolactin, AMH. Results: The prevalence of positive thyroid autoantibodies in infertile women was as follows: TPOAb positive (7.5%), TGAb positive (9.9%), both TPOAb and TGAb positive (5.2%), either TPOAb or TGAb positive (12.2%). The prevalence of thyroid dysfunction in infertile women was 8.9%, specifically: subclinical hypothyroidism (4.7%), overt hypothyroidism (2.8%), subclinical hyperthyroidism (0.9%), and overt hyperthyroidism (0.5%). Conclusion: The prevalence of TPOAb positivity was 7.5%, TGAb positivity 9.9%, and thyroid dysfunction 8.9% among infertile women.

Article Details

Keywords

infertility, thyroid, thyroid dysfunction, TPOAb, TGAb, thyroid autoantibodies

References

1. Hằng Thân Thị Bích, Trâm Nguyễn Thị Phương, Sơn Trịnh Thế, and Hùng Hồ Sỹ, Thực trạng rối loạn chức năng tuyến giáp ở bệnh nhân nữ vô sinh đến khám tại Bệnh viện Phụ sản Trung ương. Tạp chí Y học Cộng đồng, 2024. 65(1).
2. Tú Nguyễn Phương, Anh Phạm Hoàng, and Anh Nguyễn Hải Phương, Khảo sát thực trạng bệnh lý tuyến giáp ở phụ nữ vô sinh khám tại bệnh viện Phụ sản Trung ương năm 2021-2023. Tạp chí Y học Dự phòng, 2024. 34(5 Phụ bản): p. 146-152.
3. Poppe, K., P. Bisschop, L. Fugazzola, G. Minziori, D. Unuane, and A. Weghofer, 2021 European Thyroid Association Guideline on Thyroid Disorders prior to and during Assisted Reproduction. Eur Thyroid J, 2021. 9(6): p. 281-295.
4. Naing, L., R.B. Nordin, H. Abdul Rahman, and Y.T. Naing, Sample size calculation for prevalence studies using Scalex and ScalaR calculators. BMC Med Res Methodol, 2022. 22(1): p. 209.
5. Inagaki, Y., K. Takeshima, M. Nishi, H. Ariyasu, A. Doi, C. Kurimoto, et al., The influence of thyroid autoimmunity on pregnancy outcome in infertile women: a prospective study. Endocr J, 2020. 67(8): p. 859-868.
6. Dhillon-Smith, R.K., A. Tobias, P.P. Smith, L.J. Middleton, K.K. Sunner, K. Baker, et al., The Prevalence of Thyroid Dysfunction and Autoimmunity in Women With History of Miscarriage or Subfertility. The Journal of Clinical Endocrinology & Metabolism, 2020. 105(8): p. 2667-2677.
7. Huang, Y., B. Xie, J. Li, F. Hang, Q. Hu, Y. Jin, et al., Prevalence of thyroid autoantibody positivity in women with infertility: a systematic review and meta-analysis. BMC Womens Health, 2024. 24(1): p. 630.
8. Taylor, P.N., D. Albrecht, A. Scholz, G. Gutierrez-Buey, J.H. Lazarus, C.M. Dayan, et al., Global epidemiology of hyperthyroidism and hypothyroidism. Nat Rev Endocrinol, 2018. 14(5): p. 301-316.
9. Chen, C.W., Y.L. Huang, C.R. Tzeng, R.L. Huang, and C.H. Chen, Idiopathic Low Ovarian Reserve Is Associated with More Frequent Positive Thyroid Peroxidase Antibodies. Thyroid, 2017. 27(9): p. 1194-1200.
10. Akande, A.A., I.A. Isah, I.S. Aliyu, and A.G. Adesiyun, Thyroid dysfunction in women of reproductive age: laboratory protocol for infertility evaluation. Ann Ib Postgrad Med, 2022. 20(1): p. 53-57.