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Date Published: 11/03/2026
Abstract Views: 42
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DOI: https://doi.org/10.51298/vmj.v559i3.17660
Issue
Vol. 559 No. 3 (2026)
Section
Các bài báo
How to Cite
Nguyễn, H. V., Lương, T. P. A., Nguyễn, T. T. D., & Nguyễn, H. Q. (2026). THE CORRELATION BETWEEN TUMOR-INFILTRATING LYMPHOCYTES (TILs) AND EPSTEIN-BARR VIRUS (EBV) STATUS IN NASOPHARYNGEAL CARCINOMA. Vietnam Medical Journal, 559(3). https://doi.org/10.51298/vmj.v559i3.17660

THE CORRELATION BETWEEN TUMOR-INFILTRATING LYMPHOCYTES (TILs) AND EPSTEIN-BARR VIRUS (EBV) STATUS IN NASOPHARYNGEAL CARCINOMA

Hoàng Việt Nguyễn, Thị Phương Anh Lương, Thị Thùy Dương Nguyễn, Hữu Quốc Nguyễn

Main Article Content

Abstract

Objective: To determine the correlation between the Tumor-Infiltrating Lymphocytes (TILs) expression and the concentration of EBV in nasopharyngeal carcinoma (NPC). Subjects and Methods: A cross-sectional study was conducted on 141 biopsy samples from patients who were diagnosed with NPC at K3 Tan Trieu Hospital, Hanoi during 2020. Results: The highest TILs prevalence at scoring 2, accounting for 42.6% (60/141); the EBV+ displayed in 125/141 cases (88.7%); and the EBV+ patients had better overall survival than the EBV- patients (p=0.001); however no significant differences were found between the TILs expression and EBV status associated with clinical characteristics (p>0.05). Conclusions: The EBV load in the tumor tissue is not significantly related to TILs levels, although TILs at mild level (scoring 2 and 3) showed EBV concentration higher than scoring 4, indicating a complex interplay between EBV, tumor immune response and clinical factors.

Article Details

Keywords

Epstein-Barr virus, TILs, Nasopharyngeal carcinoma (NPC).

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