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EVALUATION OF THE EFFICACY OF NEGATIVE PRESSURE WOUND THERAPY WITH INSTILLATION IN THE TREATMENT OF INFECTED CHRONIC WOUNDS
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Abstract
Objective: To evaluate the clinical effectiveness of Negative Pressure Wound Therapy with Instillation and dwell time (NPWTi-d) in the treatment of infected chronic wounds. Subjects and Methods: A prospective interventional study was conducted on 20 patients with infected chronic wounds treated at the Wound Healing Center, National Burn Hospital, from April 2025 to October 2025. Patients were treated with NPWTi-d, and clinical progression as well as local bacterial changes at the wound site were evaluated at four time points: before treatment (T0), after 3 days (T1), after 7 days (T2), and after 10 days (T3). Results: After an average NPWTi-d treatment duration of 9.55 days (T2 and T3), wound size decreased, odor disappeared, and the wound bed developed healthy granulation tissue. The number of P. aeruginosa and A. baumannii on the wound surface significantly decreased after treatment. Conclusion: NPWTi-d therapy promotes wound healing and effectively supports infection control by reducing the local microbial load in infected chronic wounds.
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Keywords
Chronic wound, Infection, Negative pressure wound therapy with instillation.
References
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