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Date Published: 12/01/2022
Abstract Views: 234
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DOI: https://doi.org/10.51298/vmj.v509i1.1771
Issue
Vol. 509 No. 1 (2021)
Section
Các bài báo
How to Cite
Tiến Công, B. ., Văn Thái, P. ., Cẩm Phương, P. ., Thị Hằng, Đồng ., Văn Tuyến, P. ., Anh Tuấn, H. ., & Minh Khuy, Đoàn . (2022). STUDY VALUE OF 18FDG PET/CT IN PREDICTING OF EGFR GENE MUTATION STATUS IN PATENTS WITH LUNG ADENOCARCINOMA. Vietnam Medical Journal, 509(1). https://doi.org/10.51298/vmj.v509i1.1771

STUDY VALUE OF 18FDG PET/CT IN PREDICTING OF EGFR GENE MUTATION STATUS IN PATENTS WITH LUNG ADENOCARCINOMA

Bùi Tiến Công1,2,, Phạm Văn Thái1,2, Phạm Cẩm Phương1,2, Đồng Thị Hằng3, Phạm Văn Tuyến4, Hoàng Anh Tuấn4, Đoàn Minh Khuy4
1 Hanoi Medical University
2 Nuclear Medicine and Oncology Center, Bach Mai Hospital
3 Bach Mai Hospital
4 Pathology and Cytology Center, Bach Mai Hospital

Main Article Content

Abstract

Research objective: To study the value of FDG PET/CT in predicting EGFR mutation status in patients with lung adenocarcinoma. Subjects and research method: 114 patients with lung adenocarcinoma stage IIIb and IV had FDG PET/CT scan and EGFR mutation test before treatment from November 2018 to July 2020. Results: Mean age of the patients was 62.3±8.4, male (63.2%) female (36.8%), stage IIIb (43.0%) and stage IV (57.0%) ). 43.0% of the study patients did not express PD L1, 57.0% of the study patients had a positive PD L1 test result, from weak to strong level. EGFR mutation rate and mutation-free rate were 55.3% and 44.7%, respectively. The maxSUV value at primary lung tumor in the EGFR positive group (11.2 ± 5.7) was significantly lower than that of the negative EGFR group (15.8 ± 6.2) (p=0, 04). Using the ROC chart, the area under the curve (AUC) of maxSUV in diagnosing positive EGFR  was 0.654 (p<0.05). Combining 4 factors including maxSUV, gender, and smoking status gives better positive EGFR diagnosis results, specifically, the area under the curve (AUC) of the 4 factors is 0.706 (p). <0.05). Conclusion: FDG PET/CT characteristics are relevant and valuable in predicting EGFR mutation status in lung adenocarcinoma patients.

Article Details

Keywords

Lung cancer, adenocarcinoma, FDG PET/CT, EGFR

References

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