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Date Published: 12/01/2022
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DOI: https://doi.org/10.51298/vmj.v509i1.1772
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Vol. 509 No. 1 (2021)
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Thế Đạt, N. ., Trung Thọ, L. ., & Đình Phúc, N. . (2022). STUDYING THE RATE AND TYPE OF EGFR GENE MUTATIONS AND THE EXPRESSION RATE OF P53 AND KI67 MARKERS IN PATIENTS WITH SQUAMOUS CELL CARCINOMA. Vietnam Medical Journal, 509(1). https://doi.org/10.51298/vmj.v509i1.1772

STUDYING THE RATE AND TYPE OF EGFR GENE MUTATIONS AND THE EXPRESSION RATE OF P53 AND KI67 MARKERS IN PATIENTS WITH SQUAMOUS CELL CARCINOMA

Nguyễn Thế Đạt1,, Lê Trung Thọ2, Nguyễn Đình Phúc2
1 Phu Tho General Hospital
2 Hanoi Medical University

Main Article Content

Abstract

Studying the rate and type of EGFR gene mutations and the expression rate of P53 and Ki67 markers in patients with squamous cell carcinoma. Objectives: Determine the rate and type of EGFR mutations and the expression of P53 markers and Ki67 in patients with squamous cell carcinoma of the sinonasal.The study subjects included 48 cases of squamous cell carcinoma with histopathological diagnosis, EGFR mutation test results on Colbas 4800 and immunohistochemical staining results of P53 and Ki67 markers on the machineVenatana automatic dyeing. Results: The overall mutation rate of all 4 exons was 56.3%. Point mutation L861Q (exon 21) accounted for the most (25.1%) and mutation exon 20 (T79M) accounted for the least (8.3%). There are 95% of research cases that reveal the P53 marker, in which the moderate and strong expression levels (++ and +++) are the most and equal (39.6%). 100% of the cases revealed Ki67 imprint, in which moderate expression (++) accounted for the most (58.4%), weak expression level was only 10.4%. Non-keratinizing squamous cell carcinoma has a higher rate of EGFR mutation than the keratinized group, but the rate of expression of markers P53 and ki67 is not related to the type of keratinized or non-keratinized cancer. The study results were compared and discussed.

Article Details

Keywords

Nasal squamous cell carcinoma, EGFR mutation, P53 marker, Ki67marker

References

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