ĐẶC ĐIỂM MÔ BỆNH HỌC CỦA UNG THƯ BIỂU MÔ TUYẾN TIỀN LIỆT TRÊN SINH THIẾT KIM THEO PHÂN LOẠI WHO 2016 TẠI BỆNH VIỆN BẠCH MAI

Abstract

Objectives: To describe the histopathological characteristics of prostatic adenocarcinoma on needle biopsy according to WHO 2016 classification and to evaluate the correlation between Gleason grade and histological features. Patients and Methods: A cross-sectional study on 78 patients diagnosed with prostatic adenocarcinoma at the Department of Pathology, Bach Mai Hospital (Feb 2022 – Mar 2023). All samples were H&E stained, classified according to WHO 2016, and graded using the ISUP 2014 Gleason system. Results: The mean age of patients was 72.86 ± 7.75 years, with the 70–79 age group accounting for 41%. Conventional acinar adenocarcinoma was the predominant histological subtype (89.7%), while signet-ring cell and foamy gland variants represented 6.5% and 3.8%, respectively. At least one of three types of peritumoral invasion (perineural, vascular/lymphatic, or adipose tissue) was found in 71.8% of cases. Gleason scores 9–10 (Grade Group 5) were most frequent, comprising 64% of the cohort. Significant associations were observed between Gleason grade and perineural invasion (p=0.012), vascular invasion (p=0.029), and positive biopsy core percentage (PPC) (p<0.001). Conclusions: Conventional acinar adenocarcinoma is the predominant histological subtype of prostate cancer. High Gleason grade (9–10) accounted for the majority of cases, and showed significant correlations with perineural and vascular invasion as well as PPC, underscoring their prognostic importance in prostatic adenocarcinoma.