Article Sidebar
Views pdf: 42
EFFICACY OF PROPOFOL COMBINED WITH FENTANYL FOR INTRAVENOUS ANESTHESIA IN GASTROINTESTINAL ENDOSCOPY
Main Article Content
Abstract
Objective: To compare the anesthetic efficacy and safety of a propofol-fentanyl (P-F) combination regimen versus a propofol-only (P) regimen for intravenous anesthesia in gastrointestinal endoscopy. Methods: A controlled, cross-sectional descriptive study was conducted on 230 patients (pts) aged 18-60 years, ASA physical status I or II, scheduled for gastrointestinal endoscopy. Patients were randomly allocated into 2 groups (n=115). Group P received an intravenous induction dose of propofol 1.5 mg/kg. Group P-F received intravenous fentanyl 1 mcg/kg, followed by propofol 1.5 mg/kg. Anesthesia was maintained in both groups with repeated doses of propofol 0.5 mg/kg upon signs of awakening. Key parameters assessed included induction time, total propofol dose, number of awakenings, hemodynamic and respiratory events, and patient satisfaction. Results: Compared to Group P, Group P-F had a significantly shorter induction time (2.0 ± 0.40 min vs. 2.5 ± 0.45 min, p < 0.001). The mean total propofol dose was 14% lower in Group P-F (177.6 ± 42.5 mg) than in Group P (206.6 ± 54.4 mg), (p < 0.001). The number of awakenings requiring intervention was also lower in Group P-F (2.5 ± 1.0 times) compared to Group P (3.6 ± 1.3 times), (p < 0.001). Regarding safety, the incidence of hypotension was significantly higher in Group P than in Group P-F (p = 0.03). Recovery quality was better in Group P-F, with significantly lower rates of nausea (p = 0.006), dizziness (p = 0.014), and fatigue (p < 0.001) compared to Group P. The rate of patients reporting "very satisfied" was higher in Group P-F than in Group P (p = 0.001). Conclusion: The propofol combined with fentanyl (1 mcg/kg) regimen demonstrates superior anesthetic efficacy compared to the propofol-only regimen for gastrointestinal endoscopy in ASA I-II patients. The P-F regimen provides faster induction, a 14% reduction in propofol dos, better hemodynamic stability (less hypotension) and significantly improved recovery quality and patient satisfaction
Article Details
Keywords
Propofol, fentanyl, gastrointestinal endoscopy, intravenous anesthesia, anesthetic efficacy.
References
2. Lê Văn Long, Lê Thị Lệ Hồng và Phạm Thị Minh Thư (2021), "Đánh giá hiệu quả an thần của Propofol phối hợp với Fentanyl trong nội soi đại tràng", Tạp chí Y Dược học - Trường Đại học Y dược Huế, 5(11).
3. Phạm Thị Minh Thư và các cộng sự. (2023), "Đánh giá hiệu quả an thần của propofol đơn thuần và kết hợp Fentanyl hoặc Midazolam trong siêu âm qua nội soi đường tiêu hóa trên", Tạp chí Y Dược học - Trường Đại học Y dược Huế, 2(13).
4. Chang Jie, Yang Chun (2021), "Propofol Combined with Fentanyl Is Superior to Propofol Alone in Sedation Protocols for Painless Gastrointestinal Endoscopy", Journal of Nanomaterials, 2021, pp. 1-7.
5. De Almeida, et al (2019), "Propofol vs traditional sedatives for sedation in endoscopy: A systematic review and meta-analysis.", World J Gastrointest Endosc 11(12), pp. 573-588.
6. Liu L., et al. (2025), "Efficacy and Safety of Ciprofol Alone versus Ciprofol with Fentanyl for Upper Gastrointestinal Endoscopy: A Randomized, Double-Blind, Controlled Trial", Drug Des Devel Ther, 19, pp. 5231-5241.
7. Moon S. H. (2014), "Sedation regimens for gastrointestinal endoscopy", Clin Endosc, 47(2), pp. 135-40.
8. Novotny David, et al. (2025), "Impact of opioid addition on procedural conditions during colonoscopy: a randomized trial comparing propofol-based sedation protocols", Clin Endosc, 58(5), pp. 722-730.
9. Radaelli F., et al (2008), "Technical performance of colonoscopy: the key role of sedation/analgesia and other quality indicators", Am J Gastroenterol, 103(5), pp. 1122-30.
10. Sahinovic MM, Struys MMRF and Absalom AR (2018), "Clinical Pharmacokinetics and Pharmacodynamics of Propofol", Clin Pharmacokinet, 57(12), pp. 1539-1558.