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CHARACTERISTICS AND OUTCOMES IN THE TREATMENT OF SEVERE PNEUMONIA WITH ADENOVIRUS POSITIVE SPUTUM - PCR RESULTS IN CHILDREN AGED FROM 2 MONTH TO 5 YEARS IN CHILDREN'S HOSPITAL 1
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Abstract
Objectives: To describe the characteristics and the outcomes in treating severe pneumonia cases with adenovirus positive sputum PCR results. Subjects and methods: The retrospective study was conducted concerning a series of 55 children cases from 2 months to 5 years old at Children's Hospital 1 from April 2018 to March 2020. Results: About a third of cases require mechanical ventilation and nearly a half of them died. Factors associated with the risk of mechanical ventilation include: young age (≤ 12 months), prolonged fever, hepatomegaly, shock, leukopenia, elevated liver enzymes, and the high number of adenovirus copies, especially above 72500 x103 copies. 80% of cases require the use of three or more antibiotics which are all broad-spectrum antibiotics. Median hospital stay is 25 days. The most common complication is sepsis (45.5%). The mortality rate in the study is 16.4%. Some related factors such as the rate of hepatomegaly, leukopenia, anemia, increased AST > 100U/L, mechanical ventilation, sepsis, shock… are higher in the mortality group than in the survival group, the difference is statistically significant. Conclusion: Severe adenovirus pneumonia in children under 5 years of age shows a severe progression. The hospital stay in those cases is long and the mortality rate is high, despite intensive treatments with respiratory support and broad-spectrum antibiotics.
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Keywords
pneumonia, adenovirus, polymerase chain reaction, children
References
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