TÌNH HÌNH ĐỒNG NHIỄM EPSTEIN-BARR VIRUS VỚI HELICOBACTER PYLORI CỦA NGƯỜI DÂN TẠI THÀNH PHỐ CẦN THƠ NĂM 2025

Abstract

Background: Gastric cancer (GC) is the fifth most common cancer worldwide in terms of incidence and the fourth leading cause of cancer-related mortality, following lung cancer, liver cancer, and colorectal cancer [5]. Gastric cancer may result from multiple causes; however, co-infection with Epstein–Barr virus (EBV) and Helicobacter pylori has been classified as a Group I carcinogenic factor and is closely associated with malignant tumors in humans [2]. Identifying the relationship of co-infection plays a crucial role in the treatment and prevention of gastric diseases, especially gastric cancer, helping the public better understand the harmful effects of the disease and supporting the development of more effective treatment regimens. We conducted the study entitled “The status of co-infection with Epstein–Barr virus and Helicobacter pylori among residents in Can Tho City in 2025” with the following objectives: to determine the prevalence of co-infection and to investigate factors associated with EBV and H. pylori co-infection in Can Tho City in 2025.” Objectives: To determine the prevalence of single infection and co-infection, and to investigate several factors associated with Epstein–Barr virus and Helicobacter pylori infection in Can Tho City in 2025. Materials and methods: A cross-sectional descriptive study was conducted among children under 16 years of age and household members in two communes of Can Tho City from January 2025 to October 2025. Results: The prevalence of positive H. pylori IgG/IgM was 76.4%; positive CIM was 38.7%; EBV-VCA-IgG/IgM positivity was 76.8%; EBV-DNA positivity was 21.9%; and the rate of EBV and H. pylori co-infection was 60.6%. Poor personal hygiene behaviors and unfavorable environmental sanitation conditions were high-risk factors associated with H. pylori and EBV infection. Conclusion: The study recorded a co-infection rate of EBV and H. pylori of 60.6%. Personal hygiene behaviors and poor environmental sanitation conditions were significantly associated with H. pylori and EBV infection.