PREVALENCE AND CLINICAL CHARACTERISTICS OF HEART FAILURE WITH IMPROVED EJECTION FRACTION AFTER ONE YEAR OF OPTIMAL MEDICAL THERAPY AT TAM DUC HEART HOSPITAL

Kim Tuyến Lê, Duy Ngọc Anh Trương

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Abstract

Objective: To determine the prevalence and clinical characteristics of heart failure with improved ejection fraction (HFimpEF) in patients with chronic heart failure with reduced ejection fraction after 1 year of treatment. Methods: A retrospective cohort study was conducted on 160 patients with LVEF < 40% treated at Tam Duc Heart Hospital from June 2022 to June 2023. HFimpEF was defined as an increase in LVEF > 10% from baseline and a second LVEF > 40%. Results: The mean age was 59.75 + 14.62 years, 72.5% were male. Usage of guideline-directed medical therapy was high: ACEi/ARB/ARNI (96.9%), Beta-blockers (88.8%), MRAs (86.3%), and SGLT2i (69.4%). After 1 year, 44 patients met HFimpEF criteria (27.5%). The improved group showed significant reduction in LVMI (142 vs 100.5 g/m2 p<0.001) and increase in median LVEF (28% to 54%, p<0.001). Conclusion: The prevalence of HFimpEF was 27.5% with optimal medical therapy. Adherence to multimodal treatment significantly improves cardiac structure and function.

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References

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