EFFECTIVENESS OF COMPLETE AND EARLY VITRECTOMY FOR ACUTE POST-CATARACT ENDOPHTHALMITISVMNN

Anh Đức Hứa, Thanh Tùng Ngô, Nhật Minh Lê, Nguyễn Quỳnh Hương Đào, Thi Hoàng Lan Võ

Main Article Content

Abstract

Purpose: To evaluate the efficacy and safety of complete and early vitrectomy for endophthalmitis (CEVE) in acute post-cataract endophthalmitis (APCE) and to identify predictors of treatment outcome. Methods: Uncontrolled clinical intervention conducted at Ho Chi Minh City Eye Hospital (Jan–Aug 2022). Thirty eyes from 30 patients with APCE ≤ 6 weeks after PHACO and visual acuity (VA) ≥ light perception but no red reflex underwent CEVE within 24 h of admission. LogMAR VA and vitreous haze (EVS scale) were assessed pre-operatively and at 1 week, 1 month and 3 months. Results: Mean age 60,7 ± 11,3 years; 73,3% male. Mean logMAR VA improved from 2,38 ± 0,16 to 0,63 ± 0,64 at 3 months (p < 0,0001); 66,7% achieved VA ≥ 0,5 and 76,7% VA ≥ 0,1. Vitreous haze improved to grade ≤ 2 in 90,0% of eyes. Overall (anatomic + functional) success was 76,7%. Positive culture rate 66,7%: coagulase-negative Staphylococcus 56,7%; Gram-negative 6,7%. Complications: macular pathology 20%, retinal detachment 6,7%, iris neovascularisation 3,3%. Shorter interval PHACO-symptom (p = 0,021) and poorer baseline VA (p = 0,035) predicted better outcomes. Conclusions: CEVE provides high anatomical and functional success with low complication rates in APCE. Early intervention and baseline vision are key determinants of prognosis.

Article Details

References

1. Miller JJ, Scott IU, Flynn HW Jr, et al. Acute-onset endophthalmitis after cataract surgery (2000-2004): incidence, clinical settings, and visual acuity outcomes after treatment. Am J Ophthalmol. 2005;139(6):983-987.
2. Endophthalmitis Vitrectomy Study Group. Results of the Endophthalmitis Vitrectomy Study: a randomized trial of immediate vitrectomy and of intravitreous antibiotics for the treatment of postoperative bacterial endophthalmitis. Arch Ophthalmol. 1995;113(12):1479-1496.
3. Han DP, Wisniewski SR, Wilson LA, et al. Spectrum and susceptibilities of microbiologic isolates in the Endophthalmitis Vitrectomy Study. Am J Ophthalmol. 1996;122(1):1-17.
4. Durand ML. Bacterial and fungal endophthalmitis. Clin Microbiol Rev. 2017;30(3): 597-613.
5. Patel SN, Storey P, Pancholy M, et al. Changes in practice patterns for the management of endophthalmitis. Retina. 2019;39(4):718-724.
6. Dave VP, Pathengay A, Schwartz SG, Flynn HW Jr. Endophthalmitis following pars plana vitrectomy: a literature review of incidence, causative organisms, and treatment outcomes. Clin Ophthalmol. 2014;8:2183-2188.
7. Wykoff CC, Flynn HW Jr, Miller D, Scott IU, Alfonso EC. Exogenous fungal endophthalmitis: microbiology and clinical outcomes. Ophthalmology. 2008;115(9):1501-1507.
8. Maguire JI. Postoperative endophthalmitis: optimal management and the role and timing of vitrectomy surgery. Eye (Lond). 2008;22(10): 1290-1300.
9. Eckardt C. Transconjunctival sutureless 23-gauge vitrectomy. Retina. 2005;25(2):208-211.
10. Bernard A, Bron AM, Creuzot-Garcher C, et al. Complete and early vitrectomy for endophthalmitis with good visual outcomes. Graefes Arch Clin Exp Ophthalmol. 2020;258(4): 845-850.