TÌM HIỂU MỐI LIÊN QUAN KIỂU GEN ICEA, CAGA, VACA CỦA HELICOBACTER PYLORI VÀ MÔ BỆNH HỌC Ở BỆNH NHÂN UNG THƯ DẠ DÀY

Abstract

Background: Gene cagA and vacA are particularly noticeable in gastric cancer. There have been few studies on the analysis of iceA gene expression related to H. pylori cagA and vacA genes in gastric cancer patients. Patients and Methods: The objective of this study was to investigate the expression of H. pylori with the iceA, cagA, vacA positive have relationship with histopathology of gastric cancer. Results: The gastric cancer patients with poor differentiated image accounted for the highest proportion in both cagA and vacA positive groups at 55.4% and 54.5%. There was no difference in the iceA1 and iceA2 genotypes between tubular and ring cells in gastric cancer patients with p> 0.05. It is not possible that the secretory contains H. pylori that carries the iceA gene. The iceA1 genotype accounts for 54% in the poorly differentiated group, and 32% in the medium differentiated group. The iceA2 genotype accounts for 50% in the poorly differentiated group and 40% in the medium differentiated group. The difference between genotypes A1 and A2 in patients with gastric cancer in the moderately and poorly differentiated group was statistically significant with p <0.05.