KẾT QUẢ THỤ TINH TRONG ỐNG NGHIỆM CỦA NHÓM BỆNH NHÂN POSEIDON 3, 4 ĐƯỢC KÍCH THÍCH BUỒNG TRỨNG BẰNG PHÁC ĐỒ CÓ MỒI PROGESTIN

Abstract

Objective: To investigate the quantity and quality of oocytes and embryos, as well as the pregnancy outcomes, in POSEIDON Groups 3 and 4 patients undergoing ovarian stimulation with the Progestin-Primed Ovarian Stimulation (PPOS) protocol. Materials and Methods: This was a retrospective and prospective cross-sectional descriptive study involving 86 patients belonging to POSEIDON Groups 3 and 4 who underwent In Vitro Fertilization (IVF) at Phuong Dong High-Tech Center for Infertility and Andrology (Phuong Dong General Hospital). Patients were divided into two groups: under 35 years and over 35 years, and were stimulated using the PPOS protocol. The following parameters were evaluated: number of MII oocytes, fertilization rate, Day 3 embryo rate, Day 5 embryo (blastocyst) rate, clinical pregnancy rate, ongoing pregnancy rate, and biochemical pregnancy rate. Results: The number of MII oocytes in POSEIDON group 3 was significantly higher than that in POSEIDON group 4. The fertilization rate and day 3 embryo rate were comparable between the two groups. However, the blastocyst formation rate in POSEIDON group 3 was significantly higher compared to POSEIDON group 4 (36.8 ± 3.8% vs. 27.3 ± 8.6%). The clinical pregnancy and ongoing pregnancy rates were significantly higher in group 3 than in group 4. The biochemical pregnancy rate was similar between the two groups. Conclusion: The clinical and ongoing pregnancy rates in POSEIDON group 3 were higher than those in POSEIDON group 4. The PPOS protocol can be effectively applied to patients in both POSEIDON groups 3 and 4, demonstrating particularly high success rates in POSEIDON group 3.