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TREATMENT OUTCOMES OF SEBORRHEIC DERMATITIS WITH ITRACONAZOLE AT C HOSPITAL, DA NANG IN 2025
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Abstract
Objective: To compare the therapeutic efficacy of two oral Itraconazole regimens in the treatment of seborrheic dermatitis at Da Nang C Hospital. Methods: A prospective, non-controlled clinical intervention study was conducted on 60 patients with moderate to severe seborrheic dermatitis. Two regimens were compared: (1) Itraconazole 100 mg twice daily for 1 week, followed by a 3-week break, repeated for 2 cycles; (2) Itraconazole 100 mg twice daily continuously for 2 months. Efficacy was assessed using the SDASI score and clinical symptoms after 1 and 2 months of treatment. Results: Among 60 patients, 81.7% were male, mostly aged 60–79 years (88.3%), with 56.7% having a disease duration of less than 3 years. The most common symptoms were itching (96.7%), erythema (83.3%), symmetrical lesions (70.0%), and well-defined borders (66.7%), predominantly located on the scalp (80.0%) and face (73.3%). After 2 months of treatment, Regimen 2 achieved 73.4% very good and good responses, compared with 33.3% in Regimen 1 (p = 0.015), indicating significantly better efficacy. Conclusion: Itraconazole is an effective and safe option for treating moderate to severe seborrheic dermatitis, with the continuous 2-month regimen demonstrating superior outcomes.
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Keywords
Seborrheic dermatitis, itraconazole, SDASI, treatment, Da Nang C Hospital.
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