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Date Published: 13/01/2022
Abstract Views: 548
Views PDF: 313
DOI: https://doi.org/10.51298/vmj.v509i2.1786
Issue
Vol. 509 No. 2 (2021)
Section
Các bài báo
How to Cite
Văn Quân, L. ., Văn Mão, C. ., Việt Nam, N. ., & Trọng Nghĩa, N. . (2022). ACUTE TOXICITY OF THE VIETNEM GREEN COFFEE BEAN EXTRACT IN EXPERIMENTAL ANIMALS. Vietnam Medical Journal, 509(2). https://doi.org/10.51298/vmj.v509i2.1786

ACUTE TOXICITY OF THE VIETNEM GREEN COFFEE BEAN EXTRACT IN EXPERIMENTAL ANIMALS

Lê Văn Quân1,, Cấn Văn Mão1, Nguyễn Việt Nam2, Nguyễn Trọng Nghĩa2
1 Vietnam Military Medical University
2 108 Military Central Hospital

Main Article Content

Abstract

Objective: To assses acute toxicity of the Vietnam green coffee bean extract in mice. Methods: The acute toxicity of the product was evaluated through 2 phases: limited test and main test. In the limited test, 2 animals were administrated for each dose in series doses to find the dose in which 01 of 2 animals dead. From this dose, in the main test, series doses were contributed to series animal groups to measure LD50. Toxic symptoms or deaths in amimals were observed within 72 hours. Results: In the limited test, at dose 5000mg/kg, both animals were not dead with 72 hours. In the main test, within 72 hours, toxic symptoms or deaths in animals were not found. Body weights of all animals were not decreased. Histological images of livers and kidneys in all animals were normal at all series doses including 500mg/kg, 1000mg/kg, 2000mg/kg and 5000mg/kg. Conclusion: The Vietnam green coffee bean extracts, LD50 of this product was higher than 5000mg/kg.

Article Details

Keywords

Acute toxicity, Vietnam green coffee bean extract, mice

References

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