ĐÁNH GIÁ VAI TRÒ CỦA CÁC CHỈ SỐ TIỂU CẦU TRONG CHẨN ĐOÁN THIẾU MÁU THIẾU SẮT Ở TRẺ EM

Abstract

Background: Iron deficiency anemia is the most common hematological disorder in children. IDA may lead to reactive thrombocytosis and, less commonly, thrombocytopenia. Therefore, we conducted this study with two objectives: (1) to describe certain clinical and laboratory characteristics, and (2) to evaluate the predictive value of selected platelet indices in diagnosing iron deficiency anemia in children. Subjects and methods: This was a cross-sectional descriptive study including 30 children diagnosed with iron deficiency anemia and healthy children who were non-anemic and non-iron deficient undergoing routine health examinations at Hue University of Medicine and Pharmacy Hospital. Receiver operating characteristic (ROC) curve analysis was performed to calculate the area under the curve (AUC) and determine the optimal cutoff values. Results: The platelet count in the iron deficiency anemia group was significantly higher than that in the control group (419.12 ± 128.93 G/l vs. 293.67 ± 71.57 G/l; p < 0.05). In addition, platelet count and mean platelet volume/the platelet ratio demonstrated AUC values of 0.824 and 0.813 , respectively, indicating good predictive ability, sensitivity, and specificity in diagnosing iron deficiency anemia in children. Conclusion: Platelet count and the mean platelet volume/platelet count ratio can be considered as suggestive indices for the diagnosis of iron deficiency anemia in children.