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Date Published: 13/01/2022
Abstract Views: 296
Views PDF: 152
DOI: https://doi.org/10.51298/vmj.v509i2.1787
Issue
Vol. 509 No. 2 (2021)
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Các bài báo
How to Cite
Thị Thu Hiền, N. ., Văn Trân, P. ., & Việt Thắng, L. . (2022). ROLE PF PLASMA IgA, IgG AND IgM LEVELS IN PREDICTION OF RESPONSE TO TREATMENT IN ADULTS WITH PRIMARY NEPHROTIC SYNDROME. Vietnam Medical Journal, 509(2). https://doi.org/10.51298/vmj.v509i2.1787

ROLE PF PLASMA IgA, IgG AND IgM LEVELS IN PREDICTION OF RESPONSE TO TREATMENT IN ADULTS WITH PRIMARY NEPHROTIC SYNDROME

Nguyễn Thị Thu Hiền1,, Phạm Văn Trân2, Lê Việt Thắng2
1 Phu Tho Medical College
2 Military Hospital 103, Vietnam Military Medical University

Main Article Content

Abstract

Objectives: Determination of the predictive value of non-response of plasma IgA, IgG and IgM levels to corticosteroid therapy in adults with primary nephrotic syndrome (NS). Subjects and Methods: Longitudinal follow-up study on 57 patients diagnosed with primary NS. Assessment of response to treatment was based on 24-hour proteinuria during the course of treatment. Plasma IgA, IgG and IgM concentrations were determined by ELISA method, at day 2 of the admission. Results: After treatment, the median 24-hour proteinuria decreased significantly compared to before treatment, p<0.001. There were 19.4% of patients did not respond to corticosteroid treatment. The group of non-response patients had serum ure, creatinine higher, glomerular filtration rate lower than those of the response group, p<0.05. There was no difference in IgA, IgG and IgM concentrations between responders and nonresponders, p>0.05. Conclusion: Plasma IgA, IgG, and IgM are not predictive of response to corticosteroid therapy in adults with primary nephrotic syndrome.

Article Details

Keywords

Plasma IgA, IgG and IgM Levels, Adult Primary Nephrotic Syndrome, Predictive value of no response to treatment

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