ĐẶC ĐIỂM GIẢI PHẪU BỆNH CỦA UNG THƯ BIỂU MÔ ĐẠI TRỰC TRÀNG TẠI BỆNH VIỆN UNG BƯỚU ĐÀ NẴNG

Abstract

Background: Colorectal cancer is one of the most common cancers in the world. Objectives: To comment on pathological features of colorectal and rectal carcinoma by classification of  the World Health Organization in 2010. Determining the association between some pathological factors of colorectal carcinoma. Method: A cross-sectional descriptive study  of 156 cases that have had surgery and diagnosed histopathology as colorectal and rectal carcinoma, at Da Nang Oncology Hospital from January 2018 to the end of August 2020. Re-read the copies, classify the histological type, histological grade, invasiveness, lymph node metastasis, tumor budding, dirty necrosis, intraepithelial lymphocytes according to WHO 2010 classification. Results: Adenocarcinoma NOS has the highest rate of 80.1%. The moderately differentiated histology accounted for the highest rate of 75.2%, the pT3 stage accounted for the highest rate of 60.3%. Rate of lymph node metastasis is 47.5%; dirty necrosis rate is 41.7%; intraepithelial lymphocytes accounts for 14.7%; tumor budding accounted for 33.3%. There is a relationship between dirty necrosis, intraepithelial lymphocytes, and tumor budding with invasiveness. Conclusion: Most common adenocarcinoma NOS. The moderately differentiated histology accounted for the highest percentage, most of the disease was detected in the late stage. The rates of dirty necrosis, budding of tumors in the stage T3 and T4 have higher than these rates in T1 and T2 stages. Meanwhile, in the T1 and T2 stages, the intraepithelial lymphocytes rate is higher in the T3 and T4 stages.