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Date Published: 13/01/2022
Abstract Views: 377
Views PDF: 238
DOI: https://doi.org/10.51298/vmj.v509i2.1795
Issue
Vol. 509 No. 2 (2021)
Section
Các bài báo
How to Cite
Mỹ Hạnh, B. ., & Văn Tú, L. . (2022). THE OUTCOMES OF VENOUS THROMBOEMBOLISM PROPHYLAXIS USING RIVAROXABAN VERSUS WARFARIN DURING AND AFTER SURGERY. Vietnam Medical Journal, 509(2). https://doi.org/10.51298/vmj.v509i2.1795

THE OUTCOMES OF VENOUS THROMBOEMBOLISM PROPHYLAXIS USING RIVAROXABAN VERSUS WARFARIN DURING AND AFTER SURGERY

Bùi Mỹ Hạnh1,2,, Lê Văn Tú1,2
1 Hanoi Medical University
2 Hanoi Medical University Hospital

Main Article Content

Abstract

Objectives: To evaluate the treatment outcome of VTE prophylaxis with warfarin and rivaroxaban during and after surgery. Subjects and methods: A retrospective review of 10870 surgical patients aged >18 years from January 1, 2017 to September 31, 2018 who received anticoagulation with warfarin or rivaroxaban. Of these, 4191 patients were prevented by warfarin and 6679 were prevented by rivaroxaban. Result: During the postoperative hospital stay, there were 37/6679 (0.6%) patients treated with rivaroxaban and 52/4191 (1.2%) patients treated with warfarin being diagnosed as having VTE (including pulmonary embolism and lower extremities deep venous thrombosis). At the same time, after 90 days of discharge, 36/6679 (0.5%) patients who received rivaroxaban prophylaxis developed VTE, which is less than 51/4191 (1.2%) patients with warfarin prophylaxis. The rate of bleeding complications in the warfarin prophylactic group was higher than in the rivaroxaban prophylaxis group (7.3% and 4.2%) with statistical significance (p<0.05). Among hemorrhagic complications, the majority were cerebral infarction (3.7% in the prophylactic group with rivaroxaban and 5.9% in the prophylactic group with warfarin) in addition to gastrointestinal bleeding and some other bleeding complications. Conclusion: Rivaroxaban reduced the rate of VTE recurrence and did not increase the risk of bleeding complication in postoperative patients in comparison with warfarin, the difference was statistically significant.

Article Details

Keywords

rivaroxaban, warfarin, venous thromboembolism

References

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