ĐẶC ĐIỂM LÂM SÀNG VÀ CẬN LÂM SÀNG CỦA NHIỄM KHUẨN SƠ SINH SỚM TẠI BỆNH VIỆN ĐA KHOA QUỐC TẾ VINMEC TIME CITY

Abstract

Objectives: This study aimed to describe the clinical and paraclinical characteristics of early-onset neonatal sepsis at Vinmec Times City International General Hospital. Subjects and Methods: A cross-sectional descriptive study was conducted on 124 neonates diagnosed with early-onset neonatal sepsis admitted to the Neonatal Department of Vinmec Times City International General Hospital from January 2023 to December 2023. Results: The most common clinical manifestations of early-onset neonatal sepsis were respiratory distress, including nasal flaring, grunting, and chest retractions, as well as abnormalities in body temperature. The most frequent admission diagnoses were respiratory failure (41.1%) and jaundice (10.5%). Leukocytosis with a white blood cell count exceeding 20 G/L was observed in 41.9% of patients. Elevated inflammatory markers, including C-reactive protein (CRP) ≥ 10 mg/dL and increased procalcitonin levels, were found in 22.6% and 44.4% of cases, respectively. The rate of positive blood cultures was low, accounting for only 1.6%. Conclusion: Early-onset neonatal sepsis predominantly presents with clinical signs of respiratory distress and abnormal body temperature, with respiratory distress being the most common reason for hospital admission. Regarding paraclinical findings, elevated white blood cell counts and increased inflammatory markers such as CRP and procalcitonin were relatively common; however, the rate of positive blood cultures remained low.