CLINICAL AND PARACLINICAL CHARACTERISTICS OF SUBARACHNOID HEMORRHAGE DUE TO RUPTURED CEREBRAL ANEURYSM: A MULTICENTER STUDY

Tưởng Lân Vũ 1,2, Hồng Sơn Nguyễn 1, Văn Ninh Dương 3, Bùi Hải Hoàng 2, Quốc Chính Lương 1,4, Xuân Cơ Đào 1,4,
1 Bach Mai Hospital
2 Hanoi Medical University
3 Dien Bien General Hospital
4 University of Medicine and Pharmacy, Vietnam National University, Hanoi

Main Article Content

Abstract

Objectives: To describe the clinical and paraclinical characteristics (including imaging) of patients with subarachnoid hemorrhage (SAH) due to ruptured cerebral aneurysm. Subjects and Methods: A retrospective descriptive study of 330 patients at Bach Mai Hospital and Hanoi Medical University Hospital from January 2020 to August 2023. Results: The median age was 58 (IQR: 50-65), with 57.3% being female. The most common initial symptoms were headache (86.1%) and loss of consciousness (37.9%). Paraclinical findings showed an average white blood cell count of 14.75 ± 5.56 G/l and blood glucose of 8.42 ± 2.99 mmol/l. Imaging revealed that the most common aneurysm locations were the anterior communicating artery (32.7%), internal carotid artery (25.8%), and middle cerebral artery (21.8%). Intraventricular hemorrhage was present in 67.6% of cases, and Fisher grade IV accounted for 70.8%. Conclusion: SAH due to ruptured cerebral aneurysm is prevalent in middle-aged women, characterized by severe clinical presentation and diverse imaging findings, predominantly involving anterior circulation aneurysms.

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References

1. GBD 2019 Stroke Collaborators. Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol. 2021;20(10):795-820. doi:10.1016/S1474-4422(21)00252-0
2. Rehman S, Phan HT, Reeves MJ, et al. Case-Fatality and Functional Outcome after Subarachnoid Hemorrhage (SAH) in INternational STRoke oUtComes sTudy (INSTRUCT). J Stroke Cerebrovasc Dis Off J Natl Stroke Assoc. 2022;31(1):106201. doi:10.1016/j.jstrokecerebrovasdis.2021.106201
3. Hoh BL, Ko NU, Amin-Hanjani S, et al. 2023 Guideline for the Management of Patients With Aneurysmal Subarachnoid Hemorrhage: A Guideline From the American Heart Association/American Stroke Association. Stroke. 2023;54(7). doi:10.1161/STR.0000000000000436
4. van Gijn J, Kerr RS, Rinkel GJ. Subarachnoid haemorrhage. The Lancet. Published online 2007. doi:10.1016/S0140-6736(07)60153-6
5. Darkwah Oppong, Skowronek, Pierscianek, Gembruch, Et. A. Aneurysmal intracerebral hematoma: Risk factors and surgical treatment decisions. Clin Neurol Neurosurg. Published online 2018. doi:10.1016/j.clineuro.2018.07.014
6. Wan A, Jaja BNR, Schweizer TA, Macdonald RL. Clinical characteristics and outcome of aneurysmal subarachnoid hemorrhage with intracerebral hematoma. J Neurosurg. 2016;125(6):1344-1351. doi:10.3171/2015.10.JNS151036
7. Güresir E, Beck J, Vatter H, et al. Subarachnoid hemorrhage and intracerebral hematoma: incidence, prognostic factors, and outcome. Neurosurgery. 2008;63(6):1088-1093; discussion 1093-1094. doi:10.1227/01.NEU.0000335170.76722.B9
8. Vlak MH, Algra A, Brandenburg R, Rinkel GJ. Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: a systematic review and meta-analysis. Lancet Neurol. 2011;10(7):626-636. doi:10.1016/S1474-4422(11)70109-0
9. Connolly ES, Rabinstein AA, Carhuapoma JR, et al. Guidelines for the Management of Aneurysmal Subarachnoid Hemorrhage: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2012;43(6):1711-1737. doi:10.1161/STR.0b013e3182587839
10. Steiner T, Juvela S, Unterberg A, et al. European Stroke Organization guidelines for the management of intracranial aneurysms and subarachnoid haemorrhage. Cerebrovasc Dis. 2013;35(2):93-112. doi:10.1159/000346087