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Issue: Vol. 561 No. 1 (2026)
Section: Các bài báo
DOI: 10.51298/vmj.v561i1.18089
Date Published: 06/06/2026
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Downloads 59
How to Cite
Đoàn , T. K. C., Võ , T. B. T., Ngô , Đ. L., & Trương , N. M. (2026). PLASMA HOMOCYSTEINE LEVELS AND THEIR INDEPENDENT ASSOCIATION WITH CAROTID ATHEROSCLEROSIS IN PATIENTS WITH TYPE 2 DIABETES. Vietnam Medical Journal, 561(1). https://doi.org/10.51298/vmj.v561i1.18089

PLASMA HOMOCYSTEINE LEVELS AND THEIR INDEPENDENT ASSOCIATION WITH CAROTID ATHEROSCLEROSIS IN PATIENTS WITH TYPE 2 DIABETES

Thị Kim Châu Đoàn 1, , Thị Bích Trâm Võ 2, Đức Lộc Ngô 1, Ngọc Mai Trương 3
1 Can Tho University of Medicine and Pharmacy
2 Hoan My Cuu Long Hospital
3 Can Tho University of Medicine and Pharmacy Hospital

Main Article Content

Abstract

Background: Homocysteine (Hcy) is recognized as an independent risk factor for atherosclerosis; however, data regarding this association among patients with type 2 diabetes (T2D) in Vietnam remain limited. Objectives: This study aimed to investigate plasma Hcy levels and analyze their independent association with carotid intima-media thickness (cIMT) and the presence of carotid plaques in T2D patients. Materials and methods: A cross-sectional study was conducted on 134 T2D patients at Can Tho University of Medicine and Pharmacy Hospital from August 2022 to April 2024. Participants were stratified by Hcy quartiles to evaluate clinical characteristics and carotid ultrasound parameters. Data were analyzed using R software (version 4.5.0), utilizing statistical tests and multivariable linear regression models. Results: Elevated Hcy levels were significantly associated with smoking and reduced estimated glomerular filtration rate (p < 0.001). Mean cIMT and the prevalence of carotid plaques were significantly higher in the upper Hcy quartiles (p < 0.05). Multivariable regression analysis confirmed Hcy as an independent factor associated with increased cIMT (Beta = 0.19, p = 0.007), exhibiting a linear correlation (p = 0.014). Conclusion: Elevated plasma homocysteine levels are associated with impaired renal function and serve as an independent prognostic factor for carotid atherosclerotic damage in patients with type 2 diabetes.

Keywords

homocysteine, type 2 diabetes, atherosclerosis, carotid intima-media thickness, carotid ultrasound.

Article Details

References

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