MỐI LIÊN QUAN GIỮA CHỈ SỐ TRIGLYCERID – GLUCOSE VỚI MỨC ĐỘ NẶNG CỦA TỔN THƯƠNG ĐỘNG MẠCH VÀNH TRÊN BỆNH NHÂN HỘI CHỨNG MẠCH VÀNH CẤP

Abstract

Background: Accurate assessment of coronary damage is a key determinant in selecting optimal interventions and predicting prognosis. Recognized as a surrogate measure for insulin resistance, the triglyceride-glucose (TyG) index is intimately linked to atherosclerotic processes and the severity of coronary stenosis. Aims: Our study aimed to  investigate the association between the Triglyceride-glucose (TyG) index and the severity of coronary artery lesions in patients with acute coronary syndrome. Methods: A descriptive and analytical cross - sectional study was conducted on 369 patients with acute coronary syndrome who underwent coronary angiography at the Department of Interventional Cardiology, Cho Ray Hospital, from September 2024 to May 2025. Results: The mean age of the 369 patients with acute coronary syndrome was 69.0 ± 9.0 years, with males accounting for 66.7%. STEMI, NSTEMI, and unstable angina accounted for 42.8%, 46.1%, and 11.1%, respectively. Age, body mass index (BMI), history of type 2 diabetes, and dyslipidemia differed significantly among the TyG index subgroups. Lipid parameters (total cholesterol, LDL-C, triglycerides, non-HDL-C, and the non-HDL/HDL ratio) also showed significant differences among the TyG groups. The high TyG group had a higher prevalence of multivessel disease and total occlusion (p < 0.005). The Gensini score increased progressively across the TyG subgroups (p < 0.001), and the TyG index showed a weak but statistically significant positive correlation with the Gensini score (r = 0.27). Conclusion: We found that in patients with acute coronary syndrome, Gensini scores were significantly higher in the high TyG index group than in the low TyG index group. Additionally, there was a weak but statistically significant correlation between the TyG index and Gensini scores (p < 0.001).