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ASSOCIATION BETWEEN IN-HOSPITAL BLOOD PRESSURE VARIABILITY AND SHORT-TERM CARDIOVASCULAR OUTCOMES IN PATIENTS WITH ACUTE CORONARY SYNDROME
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Abstract
Background: Blood pressure variability has increasingly been recognized as an important cardiovascular risk factor; however, the prognostic role of in-hospital blood pressure variability for post-discharge outcomes in patients with acute coronary syndrome remains unclear. Objective: To evaluate the association between in-hospital systolic blood pressure variability, assessed by the standard deviation of systolic blood pressure (SD_SBP), and cardiovascular events within 120 days after discharge in patients with acute coronary syndrome. Methods: This was a prospective, single-center study conducted in 125 hospitalized patients with acute coronary syndrome. Blood pressure variability was assessed using SD_SBP derived from in-hospital blood pressure measurements. The primary outcome was the occurrence of cardiovascular events within 120 days after discharge. Associated factors were analyzed using univariable and multivariable logistic regression. Results: The study included 125 patients with acute coronary syndrome, with a mean age of 67.1 ± 11.4 years, and 66.4% were male. Among them, 30 patients (24.0%) were diagnosed with ST-segment elevation myocardial infarction, and 70 patients (56.0%) underwent percutaneous coronary intervention during hospitalization. The incidence of major cardiovascular events within 120 days after discharge was 20.8%. The optimal cutoff value of blood pressure variability for predicting short-term post-discharge cardiovascular events was an SD_SBP of 18.47 mmHg, yielding a sensitivity of 42% and a specificity of 87.9%. SD_SBP was identified as an independent predictor of post-discharge cardiovascular events in patients with acute coronary syndrome. Conclusion: Blood pressure variability assessed by the standard deviation shows moderate predictive value for the occurrence of major cardiovascular events after discharge in patients with acute coronary syndrome. In-hospital systolic blood pressure variability is an independent prognostic factor for cardiovascular events within 120 days after discharge in this patient population.
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Keywords
Acute coronary syndrome; blood pressure variability; cardiovascular events
References
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