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Issue: Vol. 561 No. 1 (2026)
Section: Các bài báo
DOI: 10.51298/vmj.v561i1.18211
Date Published: 06/06/2026
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Downloads 48
How to Cite
Mai , T. H., & Lê , Q. H. (2026). PREDICTIVE VALUE FOR PRETERM BIRTH BASED ON CERVICAL MORPHOLOGICAL CHANGES AT HANOI OBSTETRICS AND GYNECOLOGY HOSPITAL. Vietnam Medical Journal, 561(1). https://doi.org/10.51298/vmj.v561i1.18211

PREDICTIVE VALUE FOR PRETERM BIRTH BASED ON CERVICAL MORPHOLOGICAL CHANGES AT HANOI OBSTETRICS AND GYNECOLOGY HOSPITAL

Trọng Hưng Mai 1,2, , Quang Hòa Lê 1
1 Hanoi Obstetrics and Pediatrics Hospital
2 University of Medicine and Pharmacy, Vietnam National University, Hanoi

Main Article Content

Abstract

Objective: To describe the correlation between cervical morphological changes assessed by transvaginal ultrasound and the risk of preterm birth in pregnant women. Method: A prospective descriptive study was conducted on 182 pregnant women at high risk of preterm birth (history of preterm birth, late miscarriage, or short cervix < 25 mm) from June 2024 to August 2025 at Hanoi Obstetrics and Gynecology Hospital. A total of 1,227 transvaginal ultrasound examinations were performed periodically from 16 to 34 weeks of gestation. The assessed parameters included cervical length, internal os morphology (T-, Y-, V-, and U-shaped), functional cervical length, and internal os dilation. Statistical analyses were performed to determine the correlation between cervical morphological changes and the risk of preterm birth. Results: Among the 182 high-risk pregnant women, the observed preterm birth rate was 18.1%. Pregnant women with cervical morphological changes during pregnancy had an 8.58-fold higher risk of preterm birth compared with those without morphological changes. In the group without cervical morphological changes, the regression equation was: y = 34.553 + 0.027x + 0.101z, with a correlation coefficient R = 0.319. In the group with cervical morphological changes, the regression model was: y = 19.602 + 0.345x + 0.116z + 0.143t − 0.049u, with a correlation coefficient R = 0.55 (where y is gestational age at delivery, x is gestational age at ultrasound, z is cervical length, t is external cervical length, and u is internal os size). Conclusion: Cervical morphological changes are a high-value independent prognostic factor for the risk of preterm birth. The regression model in the group with cervical morphological changes demonstrated a stronger correlation than that in the group without morphological changes.

Keywords

Preterm birth, cervix, transvaginal ultrasound, cervical morphology, prediction.

Article Details

References

1. Cook CM, Ellwood DA. The cervix as a predictor of preterm delivery in “at-risk” women. Ultrasound Obstet Gynecol Off J Int Soc Ultrasound Obstet Gynecol. 2000;15(2):109-113. doi:10.1046/j.1469-0705.2000.00050.x
2. Nguyễn Đình Vũ, Huỳnh Nguyễn Khánh Trang. VAI TRÒ CỦA SIÊU ÂM NGẢ ÂM ĐẠO ĐO CHIỀU DÀI CỔ TỬ CUNG ĐỂ TIÊN LƯỢNG SANH NON Ở BỆNH NHÂN DỌA SANH NON. Tạp Chí Học Thành Phố Hồ Chí Minh. 2012;16(1):270-270.
3. To MS, Skentou C, Liao AW, Cacho A, Nicolaides KH. Cervical length and funneling at 23 weeks of gestation in the prediction of spontaneous early preterm delivery. Ultrasound Obstet Gynecol. 2001;18(3):200-203. doi:10.1046/j.1469-0705.2001.00437.x
4. Iams JD, Goldenberg RL, Meis PJ, et al. The length of the cervix and the risk of spontaneous premature delivery. National Institute of Child Health and Human Development Maternal Fetal Medicine Unit Network. N Engl J Med. 1996;334(9):567-572. doi:10.1056/NEJM199602293340904
5. Celik E, To M, Gajewska K, Smith GCS, Nicolaides KH, Fetal Medicine Foundation Second Trimester Screening Group. Cervical length and obstetric history predict spontaneous preterm birth: development and validation of a model to provide individualized risk assessment. Ultrasound Obstet Gynecol Off J Int Soc Ultrasound Obstet Gynecol. 2008;31(5):549-554. doi:10.1002/uog.5333
6. Berghella V, Tolosa JE, Kuhlman K, Weiner S, Bolognese RJ, Wapner RJ. Cervical ultrasonography compared with manual examination as a predictor of preterm delivery. Am J Obstet Gynecol. 1997;177(4):723-730. doi:10.1016/s0002-9378(97)70259-x
7. Owen J, Yost N, Berghella V, et al. Mid-trimester endovaginal sonography in women at high risk for spontaneous preterm birth. JAMA. 2001;286(11):1340-1348. doi:10.1001/jama.286.11.1340
8. Andrews WW, Copper R, Hauth JC, Goldenberg RL, Neely C, Dubard M. Second-trimester cervical ultrasound: associations with increased risk for recurrent early spontaneous delivery. Obstet Gynecol. 2000;95(2):222-226. doi:10.1016/s0029-7844(99)00483-4
9. Muniz Rodriguez A, Naert M, Colatosti Catanho A, Labovitis E, Rebarber A, Fox NS. The association between sonographic cervical length components and preterm birth in women with ultrasound- or exam-indicated cerclage. J Matern Fetal Neonatal Med. 2022;35(25):5703-5708. doi:10.1080/14767058.2021.1892061
10. Berghella V, Kuhlman K, Weiner S, Texeira L, Wapner RJ. Cervical funneling: sonographic criteria predictive of preterm delivery. Ultrasound Obstet Gynecol. 1997;10(3):161-166. doi:10.1046/j.1469-0705.1997.10030161.x
11. Berghella V, Owen J, MacPherson C, et al. Natural History of Cervical Funneling in Women at High Risk for Spontaneous Preterm Birth. Obstet Gynecol. 2007;109(4):863. doi:10.1097/01.AOG.0000258276.64005.ce