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INVESTIGATION OF ANGIOTENSIN CONVERTING ENZYME GENE INSERTION/DELETION POLYMORPHISM IN TYPE 2 DIABETIC PATIENTS WITH CHRONIC KIDNEY DISEASE
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Abstract
Objective: Investigation of polymorphisms of angiotensin converting enzyme (ACE) Insertion/Deletion in type 2 diabetic patients with chronic kidney disease (CKD). Methods: Cross-sectional study. Results: From November 2022 to November 2024, two hundred and eighty-nine type 2 diabetic patients from outpatient departments of Nhan Dan Gia Dinh hospital and University Medical Center at Ho Chi Minh City enrolled in the study. These patients had estimated glomerular filtration rate < 60 ml/min/1.73 m2 body surface area, urinary albumin/creatinine ratio (uACR) ≥ 300 mg/g and diabetic retinopathy. The average age of study population was 63,8 ± 11,0 and the rate of male was 42.6%. The median time of diabetes was 14 (9 – 20) years. Genotype II, ID and DD had the rate of 46.4%, 34.9% and 18.7%, respectively. Allele I and D had the rate of 63.8% and 36.2%, respectively. Conclusions: In type 2 diabetic patients with CKD, genotype II and allele I are prominent. There is no relationship between ACE I/D with the severity of CKD in type 2 diabetic patients.
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Keywords
chronic kidney disease, type 2 diabetes mellitus, polymorphisms of angiotensin converting enzyme gene (Insertion/Deletion)
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