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Date Published: 06/06/2026
Abstract Views: 11
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DOI: https://doi.org/10.51298/vmj.v561i1.18223
Issue
Vol. 561 No. 1 (2026)
Section
Các bài báo
How to Cite
Phạm , Đình C. M., Trần , N. Ánh, & Nguyễn , H. H. (2026). THE RELATIONSHIP BETWEEN SERUM HS-CRP LEVELS AND THE SEVERITY OF DRUG ALLERGY. Vietnam Medical Journal, 561(1). https://doi.org/10.51298/vmj.v561i1.18223

THE RELATIONSHIP BETWEEN SERUM HS-CRP LEVELS AND THE SEVERITY OF DRUG ALLERGY

Đình Cao Minh Phạm 1,, Ngọc Ánh Trần 2, Hữu Hà Nguyễn 3
1 ALMA Clinic
2 Department of Medicine, Nguyen Tat Thanh University
3 Clinical Department, Dermatology Hospital of Ho Chi Minh City

Main Article Content

Abstract

Objective: To evaluate the association between serum high-sensitivity C-reactive protein (Hs-CRP) levels and the severity of drug allergy. Methods: A cross-sectional study was conducted on 80 patients diagnosed with drug allergy at Ho Chi Minh City Dermatology Hospital from August 2015 to July 2016. Clinical data and serum Hs-CRP levels were collected for each patient. Results: Mean age was 33.7 ± 14.6; males accounted for 63.75%. Severe reactions (SJS/TEN) occurred in 21 patients (26.25%). Mean Hs-CRP was significantly higher in the severe group than in the mild group (83.01 vs 9.67 mg/L, p < 0.001). Within the severe group, TEN had higher CRP than SJS (131.15 vs 63.76 mg/L, p < 0.001). Among mild reactions, erythema multiforme and exfoliative dermatitis showed higher CRP than urticaria, fixed drug eruption, and angioedema (p < 0.001). Elevated CRP was observed in 63.75% of patients. No significant difference in Hs-CRP was found among drug classes (p = 0.497). Conclusion: Elevated serum Hs-CRP is closely associated with the severity of drug allergy. Hs-CRP may serve as a useful biomarker to support clinical assessment, especially in severe reactions like SJS and TEN.

Article Details

Keywords

drug allergy, hs-CRP, SJS, TEN, antibiotics

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