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CLINICAL MANIFESTATIONS AND LABORATORY ABNORMALITIES OF PATIENTS WITH INVASIVE PULMONARY ASPERGILLOSIS AT THE INTENSIVE CARE UNIT
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Abstract
Invasive pulmonary aspergillosis (IPA) in intensive care units is challenging due to difficult diagnosis and high mortality. An observational study was conducted on 38 patients with invasive pulmonary aspergillosis admitted to the intensive care units of Bach Mai Hospital and Hanoi Medical University Hospital from 2017 to 2024. The most common risk factors were the use of broad-spectrum antibiotics (84.4%), corticosteroid treatment (68.4%), and COPD (42.1%). Worsening respiratory insufficiency and refractory fever were the most common clinical signs. Abnormal thoracic CT imaging findings were observed in patients, including the halo sign, cavitation, and the air-crescent sign. The study revealed that patients with IPA had nonspecific clinical manifestations, often occurring in those with risk factors such as COPD, corticosteroid use, and prolonged broad-spectrum antibiotic treatment. Positive Aspergillus culture and typical findings on chest CT scan were characteristic features of IPA.
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Keywords
Invasive pulmonary Aspergillosis, hospital acquired pneumonia, COPD
References
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