MỘT SỐ YẾU TỐ LIÊN QUAN GIỮA HỘI CHỨNG CHUYỂN HÓA VỚI UNG THƯ DẠ DÀY TẠI BỆNH VIỆN TRUNG ƯƠNG THÁI NGUYÊN

Abstract

Objective: To analyze factors associated with metabolic syndrome (MetS) in patients with gastric cancer (GC) at Thai Nguyen National Hospital. Subjects and Methods: A cross-sectional descriptive study was conducted on 62 patients diagnosed with GC at Thai Nguyen National Hospital. Results: The mean age of the patients was 71.45 ± 11.21 years, with males accounting for 71.0% of the study population. The prevalence of MetS was 48.4%. The most common tumor location was the gastric antrum (54.8%), while the least common was the gastric fundus (3.2%). Regarding gross morphology, ulcerative lesions were the most frequently observed (58.0%), whereas polypoid (fungating) lesions were the least common (6.5%). Histopathological examination showed that gastric adenocarcinoma was the predominant type (67.7%), and low-grade malignancy accounted for 77.4% of cases. Elevated serum CEA levels (≥5 ng/mL) were found in 61.3% of patients, and CA72-4 levels ≥7 U/mL were observed in 40.3%. The prevalence of MetS was significantly higher among patients with tumors located in the gastric antrum, those with multiple tumors, tumor size ≥3 cm, CA72-4 levels ≥7 U/mL, and adenocarcinoma histology compared with the remaining groups (p<0.05). Conclusion: MetS was significantly associated with several clinicopathological characteristics of GC, including tumor location in the gastric antrum, multiple tumors, tumor size ≥3 cm, elevated CA72-4 levels, and adenocarcinoma histology. These findings suggest a potential role of metabolic disorders in the progression of GC.