KẾT QUẢ ĐIỀU TRỊ NGƯỜI BỆNH NGỘ ĐỘC CẤP METHANOL BẰNG PHÁC ĐỒ PHỐI HỢP LỌC MÁU TÍCH CỰC VÀ ETHANOL ĐƯỜNG UỐNG TẠI BỆNH VIỆN QUÂN Y 175

Abstract

Objective: To evaluate the therapeutic effectiveness of a combined regimen of intensive hemodialysis and oral ethanol in patients with acute methanol poisoning at Military Hospital 175. Subjects and Methods: A prospective descriptive interventional study following routine clinical practice, with a before-after treatment evaluation, was conducted on 35 patients diagnosed with acute methanol poisoning and treated with a combined regimen of intensive hemodialysis and oral ethanol at Military Hospital 175 from December 2022 to December 2024. Results: The study included 35 patients with methanol poisoning, with a mean age of 48.6 ± 13.2 years; the majority were male (88.6%). The primary source of exposure was illicit alcohol (82.9%). The median time from ingestion to hospital admission was 18 hours. Patients presented with diverse clinical manifestations and severe metabolic acidosis. Hemodialysis was initiated early (median 4 hours), with 40.0% requiring ≥ 2 sessions; all patients received ethanol therapy. The median time to pH recovery (> 7.3) was 18 hours, and the median hospital stay was 7 days. After treatment, the severity score based on the Poisoning Severity Score (PSS) improved significantly (p < 0.001). The complete recovery rate was 68.6%, with sequelae in 17.1% and mortality of 14.3%. Conclusion: The combined regimen of intensive hemodialysis and oral ethanol is effective in rapidly improving clinical status and metabolic disturbances, contributing to higher recovery rates and reduced severity in patients with acute methanol poisoning.