ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ MỘT SỐ YẾU TỐ TIÊN LƯỢNG CỦA UNG THƯ HẠ HỌNG TẠI BỆNH VIỆN FV THÀNH PHỐ HỒ CHÍ MINH

Abstract

Objective: To describe the clinical and paraclinical characteristics and to identify prognostic factors in patients with hypopharyngeal cancer at FV Hospital, Ho Chi Minh City. Subjects and Methods: A prospective descriptive longitudinal study was conducted on 57 patients with histopathologically confirmed hypopharyngeal cancer who were diagnosed and treated at FV Hospital, Ho Chi Minh City, from December 2019 to December 2021, with follow-up for overall survival until December 2025. Results: A total of 57 patients were included, with a mean age of 59.2 ± 10.8 years; 89.5% were male. Smoking and alcohol use were reported in 77.2% and 68.4% of patients, respectively. The most common presenting symptom was dysphagia (80.7%), and 66.7% had palpable cervical lymph nodes. Tumors were predominantly located in the pyriform sinus (71.9%). Most patients presented with advanced disease (T3-T4: 73.7%; stage III-IV: 86.0%), with nodal metastasis in 68.4%. The main treatment modalities were surgery combined with radiotherapy (49.1%) and concurrent chemoradiotherapy (33.3%). Overall survival rates were 93.0% at 6 months, 84.2% at 12 months, 68.4% at 24 months, 49.1% at 36 months, and 14.0% at 48 months; the mean survival time was 27.84 ± 2.18 months. Cox regression analysis identified nodal metastasis, stage III-IV, and non-curative treatment as significant adverse prognostic factors (p < 0.05). Conclusion: Hypopharyngeal cancer is predominantly diagnosed at an advanced stage, with a high rate of nodal metastasis and poor survival outcomes. Tumor stage, nodal status, and treatment modality significantly influence overall survival.