NGHIÊN CỨU MỐI LIÊN QUAN GIỮA BIỂU HIỆN MiR-203 VỚI MỘT SỐ YẾU TỐ CỦA BỆNH VẢY NẾN MẢNG

Abstract

Background: MiR-203 is a skin-specific microRNA involved in psoriasis pathogenesis. This study aimed to investigate the association between miR-203 expression and clinical features in plaque psoriasis patients. Methods: A case-control study was conducted on 37 patients with plaque psoriasis and 37 healthy controls. miR-203 expression in blood was quantified by RT-PCR and analyzed in relation to clinical factors. Results: miR-203 ΔCt value showed a moderate positive correlation with PASI score (r = 0.428; p = 0.014), suggesting that miR-203 expression decreases with increasing disease severity. However, no significant correlation between miR-203 level and patient’s clinical characteristics such as age, gender, BMI classification, smoking status, comorbidities, family history of psoriasis, disease duration, or age of onset. Conclusion: miR-203 expression correlates with disease severity in plaque psoriasis. It may serve as a prognostic biomarker for disease activity.