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Issue: Vol. 562 No. 1 (2026)
Section: Các bài báo
DOI: 10.51298/vmj.v562i1.18370
Date Published: 10/08/2026
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Downloads 17
How to Cite
Trần, T. N., Phạm, C., Phạm, H. K., Phạm, Q. P., Đinh, T. G., Nguyễn, V. M., & Trần, T. L. (2026). Prognostic value of the Bilirubin-to-Albumin (B/A) ratio in patients with solitary HBV-related hepatocellular carcinoma. Vietnam Medical Journal, 562(1). https://doi.org/10.51298/vmj.v562i1.18370

Prognostic value of the Bilirubin-to-Albumin (B/A) ratio in patients with solitary HBV-related hepatocellular carcinoma

Thảo Nguyên Trần1, , Châu Phạm1, Hồng Khánh Phạm1, Quang Phú Phạm, Trường Giang Đinh2, Văn Mạnh Nguyễn2, Tùng Lâm Trần2
1 Học viện Quân y
2 Bệnh viện Trung ương quân đội 108

Main Article Content

Abstract

Objectives: To assess the prognostic value of the bilirubin-to-albumin (B/A) ratio in predicting mortality among antiviral treatment-naive patients with solitary HBV-related hepatocellular carcinoma (HCC).


Methods: A cross-sectional analytical study with longitudinal follow-up was conducted on 111 patients diagnosed with solitary HCC who were HBsAg (+) or HBV-DNA (+) at 108 Military Central Hospital from April 2021 to October 2024. The prognostic value for mortality was assessed using the area under the ROC curve (AUC), and survival time was analyzed using the Kaplan-Meier method and Log-rank test.


Results: The B/A ratio was significantly higher in the deceased group compared to the survival group (p < 0.05). The B/A ratio demonstrated a good prognostic value for mortality with an AUC of 0.803 (p < 0.001; 95%CI: 0.704 - 0.901). At the optimal cut-off value of ≥ 0.3716, the B/A ratio yielded a sensitivity (Se) of 87.0% and specificity (Sp) of 63.5%. Kaplan-Meier analysis showed that patients with a B/A ratio < 0.3716 had a low mortality rate of 7.0%, with a median survival time that was not reached and a mean survival time of 36.19 months; whereas patients with a B/A ratio ≥ 0.3716 experienced a markedly shorter median survival time of 25.0 months (95% CI: 20.02–29.79), with a substantially higher mortality rate of 46.5%. This difference in survival curves was statistically significant (Log-rank test, p < 0.001).


Conclusion: The B/A ratio is a simple, objective index with high value in risk stratification and survival prognosis for antiviral treatment-naive patients with solitary HBV-related HCC.

Keywords

Hepatocellular carcinoma, Hepatitis B virus, Bilirubin/Albumin ratio, Solitary

Article Details

References

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