MỐI LIÊN QUAN GIỮA MỨC LỌC CẦU THẬN ƯỚC TÍNH (eGFR) VÀ MỨC ĐỘ ĐAU Ở BỆNH NHÂN THOÁI HÓA KHỚP GỐI ĐIỀU TRỊ NGOẠI TRÚ TẠI BỆNH VIỆN ĐẠI HỌC VÕ TRƯỜNG TOẢN GIAI ĐOẠN 2025-2026

Abstract

Objectives: To describe clinical and paraclinical characteristics of outpatients with knee osteoarthritis at the Musculoskeletal Center, Vo Truong Toan University Hospital, 2025-2026, and to determine the association between estimated glomerular filtration rate (eGFR) and VAS pain severity.

Methods: An analytical cross-sectional study was conducted on 70 patients aged 40 years or older with knee osteoarthritis diagnosed according to the 1991 ACR criteria and available serum creatinine results. Data on clinical features, comorbidities, NSAID use, VAS score, serum creatinine and CKD-EPI 2021 eGFR were analyzed using SPSS 26.0.

Results: Females accounted for 77.1%; patients aged 60-70 years and >70 years each accounted for 32.9%; manual laborers accounted for 57.1%. Pain on movement was reported by 100%, morning stiffness and difficulty climbing stairs by 98.6%, and restricted mobility by 92.9%. Comorbidity was present in 90.0%; hypertension in 70.0%; and 65.7% used NSAIDs regularly. Mean VAS was 6.06 ± 0.80 and mean eGFR was 84.29 ± 18.29 mL/min/1.73m². Severe pain increased from 6.7% in G1 to 38.2% in G2, 75.0% in G3a and 100.0% in G3b (p<0.001). VAS was inversely correlated with eGFR (r=-0.512; p<0.001). After adjustment, eGFR remained independently associated with VAS (B=-0.016; p=0.007).

Conclusion: Lower eGFR was associated with higher pain severity in outpatients with knee osteoarthritis. Renal function assessment should be integrated into pain management, especially in older adults, patients with comorbidities and long-term NSAID users.